定量磁敏感成像测定帕金森病脑铁沉积含量的价值OA

Objective To determine iron deposition in gray matter nuclei of Parkinson's disease(PD)by quantitative magnet-ic sensitivity imaging(QSM)and its correlation with clinical conditions,and to explore its role in the pathogenesis of PD.Methods PD patients admitted to Beijing Aerospace Central Hospital from May 2023 to May 2024 were enrolled into PD group and normal control(NC)group with similar age and sex were chosen.PD patients and NC group were subjected to magnetic resonance ima-ging,and the final QSM magnetic sensitive value(MSV)parameter graph was obtained by Matlab post-processing software.The MSV of caudate nucleus,lenticular nucleus,red nucleus,substantia nigra and dentate nucleus were measured.PD group was divided into mild disease group(Hoehn-Yahr stage≤2.5)and moderate-severe disease group(Hoehn-Yahr stage≥3.0)according to Hoehn-Yahr stage.According to part 3 of unified Parkinson's disease rating scale(UPDRS-Ⅲ),the patients were divided into low and high score groups.The differences of nuclear MSV values between different groups and their correlation with clinical conditions were compared.Results There were statistically significant differences in MSV values of multiple nuclear masses between PD groups,PD scoring groups and NC group(P<0.05).The MSV values of substantia nigra and dentate nucleus were higher,and the differences between the groups were statistically significant(P<0.05).There was correlation between the MSV values of substantia nigra and dentate nucleus and UPDRS-Ⅲ score in PD moderate-severe disease group(P<0.05).Conclusions QSM can reflect the content of iron deposition in gray matter nuclei of PD patients,and become an important imaging biomarker to evaluate the occurrence and development of PD.The content of iron deposition in substantia nigra and dentate nucleus can best reflect the severity of PD,especially the motor symptoms.