武警医学2025，Vol.36Issue(2)：106-109,4.
长期小剂量阿奇霉素治疗支气管扩张症的疗效
Curative effect of long-term low-dose azithromycin in treatment of bronchiectasis
刘晓华 1朴宇鑫 1柴文强 1范超宇 1李大文2
作者信息
- 1. 010040 呼和浩特,武警内蒙古总队医院内一科
- 2. 010040 呼和浩特,武警内蒙古总队医院外一科
- 折叠
摘要
Abstract
Objective To analyze the curative effect of long-term low-dose azithromycin in the treatment of bronchiectasis.Methods A total of 98 patients with bronchiectasis admitted to Inner Mongolian Autonomous Regional Corps Hospital of Chinese Peo-ple's Armed Police Force from June 2021 to March 2024 were divided into a control group and an observation group,with 49 cases in each group according to random number table method,The control group received conventional symptomatic treatment,while the obser-vation group received long-term low-dose azithromycin treatment on the basis of the control group.After 6 months,the clinical efficacy,dyspnea,sputum characteristics and airway inflammation were compared between the two groups.Results After treatment,the total effective rate of the observation group was 91.84%,which was higher than that of the control group(75.51%)(P<0.05).The Saint George's Respiratory Questionnaire(SGRQ)score of the observation group was(44.33±13.69),which was lower than that of the control group(58.88±14.29).The modified Medical Research Council Dyspnea Scale(mMRC)score was(2.08±0.40),which was lower than that of the control group(2.71±0.46).The differences were statistically significant(P<0.05).The 24-hour sputum vol-ume of the observation group was lower than that of the control group,and the sputum density and purulent mucus scores were lower than those of the control group.The expressions of sputum interleukin-6(IL-6),65 subunit protein(p65)and high-sensitivity C-reac-tive protein(hs-CRP)were lower than those of the control group.The differences were statistically significant(P<0.05).Conclusions The clinical value of long-term low-dose azithromycin treatment for bronchiectasis is significant,which is helpful to im-prove the curative effect of patients,relieve the degree of dyspnea,and promote the improvement of sputum characteristics and airway inflammation.关键词
支气管扩张症/小剂量/阿奇霉素/呼吸困难/痰液性状/气道炎性Key words
bronchiectasis/low dose/azithromycin/dyspnea/sputum characteristics/airway inflammation分类
医药卫生引用本文复制引用
刘晓华,朴宇鑫,柴文强,范超宇,李大文..长期小剂量阿奇霉素治疗支气管扩张症的疗效[J].武警医学,2025,36(2):106-109,4.
