武警医学2025，Vol.36Issue(2)：110-114,5.
病毒性心肌炎患者血清钙卫蛋白A4、A8/A9与病情及预后不良的关系
Relationship between serum calprotectin A4,A8/A9 and disease condition and poor prog-nosis in patients with viral myocarditis
摘要
Abstract
Objective To investigate the relationship between serum calprotectin A4(S100A4),calprotectin A8/A9(S100A8/A9)and disease condition and poor prognosis in patients with viral myocarditis(VMC).Methods A total of 151 VMC pa-tients admitted to Guangdong Provincial Corps Hospital of Chinese People's Armed Police Force from November 2020 to November 2022 were divided into a mild group(87 cases)and a severe group(64 cases)according to the severity of the disease.During the same period,90 healthy volunteers who underwent physical examination in the same hospital were selected as a healthy group.The baseline data and serum S100A4 and S100A8/A9 expression levels in the three groups at admission were compared.All VMC patients were followed up for 1 year,and divided into poor prognosis group and good prognosis group according to the occurrence of adverse e-vents.The influencing factors affecting the poor prognosis of VMC were analyzed by multivariate Logistic analysis,the predictive effica-cy of serum S100A4 and S100A8/A9 on the poor prognosis of patients was analyzed by receiver operating characteristic(ROC)curve.Results The levels of serum S100A4 and S100A8/A9 in mild and severe groups were higher than those in healthy group(P<0.05),and the levels of serum S100A4 and S100A8/A9 in severe group were higher than those in mild group(P<0.05).Compared with the good prognosis group,the poor prognosis group showed an increase in the proportion of atrioventricular block,cardiac troponin Ⅰ,crea-tine kinase isoenzyme,serum S100A4,and serum S100A8/A9 levels(P<0.05),and a decrease in left ventricular ejection fraction(P<0.05).Atrioventricular block(OR=1.850,95％CI:1.369-2.511),elevated cardiac troponin Ⅰ(OR=1.738,95％CI:1.285-2.306),elevated creatine kinase isoenzyme(OR=1.677,95％CI:1.213-2.127),elevated S100A4(OR=1.409,95％CI:1.021-1.869),and elevated S100A8/A9(OR=1.493,95％CI:1.115-1.936)were risk factors for poor prognosis of VMC,while elevated left ventricular ejection fraction(OR=0.627,95％CI:0.558-0.815)was a protective factor(P<0.05).ROC curve results showed that the AUC of serum S100A4 and S100A8/A9 to predict the poor prognosis of VMC was 0.675 and 0.719,respectively.The AUC of combining serum S100A4 and S100A8/A9 to predict the poor prognosis of VMC was 0.784,which was greater than that of S100A4 or S100A8/A9 alone.Conclusions The high expression of serum S100A4 and S100A8/A9 is related to the aggravation of VMC and the occurrence of poor prognosis in VMC patients.The combined detection of the two indicators can improve the prediction efficiency of poor prognosis in patients.关键词
病毒性心肌炎/钙卫蛋白A4/钙卫蛋白A8/A9/预后/预测价值Key words
viral myocarditis/calprotectin A4/calprotectin A8/A9/prognosis/predictive value分类
医药卫生引用本文复制引用
孙敏伊,黄燕,林更映..病毒性心肌炎患者血清钙卫蛋白A4、A8/A9与病情及预后不良的关系[J].武警医学,2025,36(2):110-114,5.基金项目
广东省医学科研基金指令性课题项目(C2020009) （C2020009）
