摘要
Abstract
Objective To explore the characteristics of heart rate variability in patients with coronary heart disease(CHD)accompanied by chronic heart failure(CHF)and analyze its correlation with the severity of the disease.Methods The clinical data of 84 patients with coronary heart disease in Traditional Chinese Medicine Hospital of Changsha from January 2022 to May 2024 were ret-rospectively analyzed and divided into two groups based on whether they had CHF or not,including 42 patients with CHD alone(CHD group)and 42 patients with CHD accompanied by CHF(CHD accompanied by CHF group),while 42 healthy subjects admitted to the same hospital during the same period were used as control group,and 24-hour holter electrocardiogram was used to observe heart rate variability indicators and its correlation with the severity of the disease.Results The standard deviation of R-R intervals(SDNN),root mean square of adjacent sinus R-R interval difference(rMMD),percentage of sinus rhythm with adjacent sinus R-R interval difference≥50 ms(PNN50),ratio of total sinus R-R intervals to the height of sinus R-R interval histogram(TRI),and fastest heart rate in the CHD accompanied by CHF group were lower than those in the control group.In addition,the SDNN,root mean square of adjacent sinus R-R interval difference(rMMD),PNN50,and TRI in the CHD accompanied by CHF group were higher than those in the CHD group(P<0.05).According to New York Heart Association(NYHA)grading system,patients with CHD accompanied by CHF were mostly diagnosed with mild heart function impairment,accounting for 40.48％,followed by moderate to severe heart function impairment.SDNN,rMSSD,PNN50,and TRI of grade Ⅳ patients were lower than those of grade Ⅱ and Ⅲ,and all indicators of grade Ⅲ patients were lower than those of grade Ⅱ(P<0.05).Pearson correlation analysis showed a negative correlation(P<0.05)between NYHA grade and heart rate variability indicators.Conclusions Patients with CHD or with CHD accompanied by CHF exhibit cardiac autonomic dysfunction and decreased heart rate variability,accompanied by different degrees of cardiac function impairment,and the indicators of heart rate variability is negatively correlated with NYHA.关键词
冠心病/慢性心力衰竭/心率变异性特点/心功能/病情程度/相关性Key words
coronary heart disease/chronic heart failure/characteristics of heart rate variability/heart function/degree of illness/correlation分类
临床医学
