中国病理生理杂志2025，Vol.41Issue(2)：369-375,7.DOI:10.3969/j.issn.1000-4718.2025.02.019
胆管反应在原发性硬化性胆管炎进展中的作用及其靶向治疗现状
Recent advances in ductular reaction in the context of primary sclerosing cholangitis:mechanistic insights and targeted therapy
摘要
Abstract
Primary sclerosing cholangitis(PSC)is an autoimmune disease characterized by chronic inflamma-tion and progressive fibrosis that affects both intrahepatic and extrahepatic bile ducts.Despite ongoing research,the under-lying mechanisms of PSC pathogenesis remain incompletely understood.The ductular reaction is not only a key pathologi-cal feature of PSC but also serves as a driving force in its progression.This review examines the promoting effects of the ductular reaction on PSC advancement from multiple perspectives,including the proliferation of biliary epithelial cells,in-flammation,and fibrosis.By providing theoretical insights into the pathogenesis of PSC,this review aims to facilitate the identification of novel therapeutic strategies.关键词
原发性硬化性胆管炎/胆管反应/炎症/纤维化Key words
primary sclerosing cholangitis/ductular reaction/inflammation/fibrosis分类
医药卫生引用本文复制引用
崔一鸣,胡博,林浩婷,王佳敏,洪健,陶萍..胆管反应在原发性硬化性胆管炎进展中的作用及其靶向治疗现状[J].中国病理生理杂志,2025,41(2):369-375,7.基金项目
国家自然科学基金面上项目(No.82473023) （No.82473023）
广东省基础与应用基础研究基金面上项目(No.2023A1515012905) （No.2023A1515012905）
