中国病理生理杂志2025，Vol.41Issue(2)：382-387,6.DOI:10.3969/j.issn.1000-4718.2025.00.002
免疫细胞来源的外泌体在动脉粥样硬化中作用的研究进展
Advancements in research on the role of exosomes derived from immune cells in atherosclerosis
摘要
Abstract
Atherosclerosis(AS)is a chronic inflammatory disease involving various immune cells and is char-acterized by lipid deposition and inflammatory response.In recent years,the field of exosome research has been rapidly developed,thereby enhancing our comprehension of their role in AS.Immune cell-derived exosomes are extracellular vesi-cles secreted by immune cells that possess specificity,stability,and biocompatibility.These exosomes have the capacity to induce diverse responses including modulating gene transcription and regulating cytokine production,thereby influenc-ing the body's inflammatory and immune response.During AS progression,these exosomes primarily participate in patho-logical processes including endothelial dysfunction,lipid deposition,vascular calcification,and plaque rupture,all of which significantly influence the development of AS.This review is focused on exploring the role of exosomes derived from monocytes,macrophages,neutrophils,lymphocytes,as well as other immune cells(neutrophils,eosinophils,mast cells,and myeloid-derived suppressor cells)in AS,aiming to offer insights for diagnosis and clinical treatment.关键词
动脉粥样硬化/免疫细胞/外泌体/炎症/免疫调节Key words
atherosclerosis/immune cells/exosomes/inflammation/immune regulation分类
医药卫生引用本文复制引用
赵依婷,秦合伟..免疫细胞来源的外泌体在动脉粥样硬化中作用的研究进展[J].中国病理生理杂志,2025,41(2):382-387,6.基金项目
国家自然科学基金面上项目(No.82374551) （No.82374551）
河南省高等学校重点科研项目(No.24B360003) （No.24B360003）
河南中医药大学2023年度研究生科研创新能力提升计划项目(No.2023KYCX080 （）
No.2023KYCX079) （）
