中国病理生理杂志2025，Vol.41Issue(2)：388-393,6.DOI:10.3969/j.issn.1000-4718.2024.00.026
组织蛋白酶K对牙周炎发展和牙周再生的影响
Influence of cathepsin K on periodontitis and periodontal regeneration
摘要
Abstract
Periodontitis is a chronic inflammatory disease primarily triggered by dysregulation of microbial communities and altered host immune response.It is clinically presented by alveolar bone resorption,which is one of the main causes of loosening of teeth and tooth loss.Cathepsin K(CTSK)is a highly expressed collagenase produced by osteo-clasts and can directly degrade matrix collagen proteins and indirectly increase osteoclast activity.The expression level of CTSK fluctuates in response to the progression of periodontal inflammation.The expression of Toll-like receptors is upregu-lated in periodontitis lesions.Pathogen-associated molecular pattern binds to relevant TLRs,initiating downstream im-mune pathways that promote receptor activator of nuclear factor-κB ligand-dependent osteoclastogenesis,along with in-creased expression of CTSK.Intervening in the process of alveolar bone resorption can be achieved through the regulation of CTSK.This paper provides a summary of the pathogenic mechanism of CTSK in periodontitis and highlights the research progress regarding the use of CTSK as a therapeutic target.The aim is to offer insights and references for the treatment of periodontitis.关键词
牙周炎/组织蛋白酶K/骨吸收/生物标志物/抑制剂Key words
periodontitis/cathepsin K/bone resorption/biomarkers/inhibitor分类
医药卫生引用本文复制引用
毛炜婷,张若琪,赵玥雯,黄珊..组织蛋白酶K对牙周炎发展和牙周再生的影响[J].中国病理生理杂志,2025,41(2):388-393,6.基金项目
国家自然科学基金青年科学基金项目(No.82104938) （No.82104938）
