中国病理生理杂志2025，Vol.41Issue(2)：403-411,9.DOI:10.3969/j.issn.1000-4718.2025.02.024
人乳头瘤病毒与头颈部鳞癌肿瘤免疫微环境相互作用的研究进展
Progress in interplay between human papillomavirus and tumor immune microenvironment of head and neck squamous cell carcinoma
摘要
Abstract
Head and neck squamous cell carcinoma(HNSCC)is currently acknowledged as an independent cause of disease.Beyond smoking and heavy alcohol use,persistent infection with high-risk human papillomavirus(HPV)is receiving increased recognition as a newly identified independent cause of this condition.The distinct clinical character-istics of HPV-related HNSCC,which are linked with a better prognosis,and its interaction with the tumor immune micro-environment,are areas of intense research focus.The specific immune response triggered by HPV and the tumor immune microenvironment are vital in the development,progression,and outcome of HNSCC.This review examines the ways HPV positive HNSCC evades the immune system,assesses the influence of HPV on the tumor immune microenvironment in HN-SCC,and explores its interaction with the body's adaptive immunity.This article presents a review on the evaluation of specific immune responses in improving the prognosis of HPV-related HNSCC and discusses the potential value of immune analysis in predicting prognosis.Furthermore,we analyze novel immune therapy strategies,mechanisms,and prognosis in HPV-related HNSCC.关键词
人乳头瘤病毒/头颈部鳞状细胞癌/肿瘤免疫微环境/免疫治疗/预后Key words
human papillomavirus/head and neck squamous cell carcinoma/tumor immune microenviron-ment/immunotherapy/prognosis分类
医药卫生引用本文复制引用
张凌楠,周思远,刘晓燕,王晶..人乳头瘤病毒与头颈部鳞癌肿瘤免疫微环境相互作用的研究进展[J].中国病理生理杂志,2025,41(2):403-411,9.基金项目
山东省自然科学基金博士基金资助项目(No.ZR2018BH026) （No.ZR2018BH026）
山东省医药卫生科技发展计划面上项目(No.2017WS231) （No.2017WS231）
山东省中医药科技青年项目(No.2020Q062) （No.2020Q062）
