中国病理生理杂志2025，Vol.41Issue(2)：412-416,5.DOI:10.3969/j.issn.1000-4718.2025.02.025
分泌蛋白Dickkopf家族在结直肠癌中的研究进展
Research progress of Dickkopf family in colorectal cancer
摘要
Abstract
Colorectal cancer(CRC)is currently the third most prevalent tumor and the second leading cause of cancer-related mortality.Abnormal Wnt/β-catenin signaling pathway is one of the key signaling pathways leading to the occurrence and development of CRC.The Dickkopf family,consisting of secreted proteins,acts as antagonists to this sig-naling pathway and significantly influences the progression of CRC.The family includes Dickkopf-1 to Dickkopf-4 secret-ed proteins,with each member exhibiting distinct roles in the context of CRC.This article aimed to provide a comprehen-sive overview of the research advancements concerning the secreted Dickkopf family's role in CRC.关键词
Dickkopf蛋白/结直肠癌/Wnt/β-catenin信号通路Key words
Dickkopf proteins/colorectal cancer/Wnt/β-catenin signaling pathway分类
基础医学引用本文复制引用
方云,王应辉,周响..分泌蛋白Dickkopf家族在结直肠癌中的研究进展[J].中国病理生理杂志,2025,41(2):412-416,5.基金项目
贵州省卫生健康委科学技术基金项目(No.gzwkj2024-467) （No.gzwkj2024-467）
