眼科新进展2025，Vol.45Issue(3)：211-215,5.DOI:10.13389/j.cnki.rao.2025.0037
广域扫频源OCTA对糖尿病视网膜病变无灌注区识别的对比及预测研究
A comparison and prediction study of wide-field swept-source optical coher-ence tomography angiography in identifying non-perfusion areas in diabetic retinopathy
摘要
Abstract
Objective To compare the differences between swept-source optical coherence tomography angiography(SS-OCTA)and ultra-wide-field fluorescein angiography(UWFA)in detecting non-perfusion areas(NPs)in patients with diabetic retinopathy(DR),to evaluate the accuracy of SS-OCTA in predicting NPs outside its visible range,and to explore the distribution patterns of NPs.Methods A retrospective analysis was made on 69 DR patients(88 eyes)who under-went both UWFA and SS-OCTA examinations at the Ophthalmology Department of Sichuan Provincial People's Hospital from December 2022 to September 2024.Manual NP labeling was conducted to compare the detection rate of NPs between the two imaging techniques.The distribution patterns of NPs and the accuracy of SS-OCTA for predicting NPs outside its visible range were also analyzed.Results In a scanning area of 20 mm x 24 mm,the overall NP detection rate by SS-OCTA was 47.40％,with UWFA taken as the standard.The NP detection rate by SS-OCTA was 51.56％in the superotemporal quad-rant,58.35％in the inferotemporal quadrant,45.50％in the superonasal quadrant,and 43.17％in the inferonasal quad-rant.Most NPs occurred in the inferonasal quadrant,accounting for 41.71％of the total NP.The accuracy of SS-OCTA in predicting NPs was 75.00％in the superonasal quadrant and 78.41％in the inferonasal quadrant.The ischemic indices(ISI)of the two imaging techniques were highly positively correlated(r2=0.74).Conclusion Although SS-OCTA can-not yet fully replace UWFA for NP detection in DR patients due to a small visible range,it is still an effective tool to assess retinal ischemia.SS-OCTA has the ability to predict NPs outside its visible range in its scanning range.The inferonasal quadrant is the region where NPs occur most frequently in DR patients,so it is suggested that special attention should be paid to this region in early diagnosis and follow-up periods.关键词
糖尿病视网膜病变/无灌注区/光学相干断层扫描血管成像/广域眼底荧光血管造影Key words
diabetic retinopathy/non-perfusion area/optical coherence tomography angiography/ultra-wide-field fluorescein angiography分类
临床医学引用本文复制引用
郭楚云,李杰,韩悦,陈丽,刘逸,成洪壮,宁欣如,沈亚丹,凌若岚,钟捷..广域扫频源OCTA对糖尿病视网膜病变无灌注区识别的对比及预测研究[J].眼科新进展,2025,45(3):211-215,5.基金项目
国家自然科学基金项目(编号:62376173) （编号:62376173）
四川省自然科学基金项目(编号:2023NSFSC0592) （编号:2023NSFSC0592）
四川省科技项目专项基金项目(编号:2021kflx002) （编号:2021kflx002）
四川省卫健委重点研发项目(编号:ZH2024-201) （编号:ZH2024-201）
成都市卫健委项目(编号:2022039) （编号:2022039）
