中国临床医学影像杂志2025，Vol.36Issue(2)：99-103,5.DOI:10.12117/jccmi.2025.02.006
非小细胞肺癌动态增强CT特征与病灶组织TTF-1、CK5/6表达的关系
Relationship between dynamic enhanced CT features and the expression of TTF-1 and CK5/6 in lesion tissues of non-small cell lung cancer
摘要
Abstract
Objective:To explore the relationship between dynamic enhanced CT features and the expression of thyroid transcription factor 1(TTF-1)and cytokeratin 5/6(CK5/6)in lesion tissues of non-small cell lung cancer(NSCLC)patients.Methods:A total of 138 patients with NSCLC diagnosed by pathological examination in Xinxiang Central Hospital from Jan-uary 2021 to June 2023 were selected for clinical study.Dynamic enhanced CT features and scanning parameters of patients with different TTF-1 and CK5/6 protein expression levels were compared,respectively.Results:Of 138 NSCLC patients,92(66.70%)had positive expression of TTF-1 protein and 73(52.90%)had positive expression of CK5/6 protein.The burr positive rate,vascular cluster sign detection rate,pleural invasion rate and lymph node metastasis rate of NSCLC patients with CK5/6 protein positive expression were significantly higher than those with CK5/6 protein negative expression(P<0.05).The perfusion value and peak height(PH)value of CK5/6 protein positive patients were higher than those of CK5/6 protein negative patients(P<0.05).Conclusion:There is no significant correlation between the expression of TTF-1 protein and the dynamic enhanced CT features and parameters in NSCLC patients.CK5/6 protein plays an important role in the development of NSCLC disease and is related to the dynamic enhanced CT features and parameters of patients.In clinical practice,it can be used as an auxiliary means to evaluate the degree of tumor development and clinical diagnosis.关键词
癌,非小细胞肺/体层摄影术,螺旋计算机Key words
Carcinoma,Non-Small-Cell Lung/Tomography,Spiral Computed分类
临床医学引用本文复制引用
孟锦,张冰凌,马啸天,李卫星..非小细胞肺癌动态增强CT特征与病灶组织TTF-1、CK5/6表达的关系[J].中国临床医学影像杂志,2025,36(2):99-103,5.基金项目
河南省医学科技攻关计划项目(LHGJ20230879). （LHGJ20230879）
