中国临床医学影像杂志2025，Vol.36Issue(2)：109-112,116,5.DOI:10.12117/jccmi.2025.02.008
磁共振mDixon-Quant技术联合肝生化指标对MAFLD脂肪定量及肝脏功能评估研究
MR mDixon-Quant technology combined with liver biochemical indicators for MAFLD fat quantification and liver function evaluation
摘要
Abstract
Objective:To explore the feasibility of using MR mDixon-Quant technology combined with liver biochemical indicators for quantitative analysis of liver fat and evaluation of liver function in rats with metabolic associated fatty liver dis-ease(MAFLD).Method:Fifty clean grade SD rats were randomly divided into two groups:the model group(n=40)and the con-trol group(n=10).The model group was fed with high-fat diet,while the control group was fed with regular diet for a total of 12 weeks.Starting from the fourth week,8 mice from the model group and 2 mice from the control group were selected ev-ery other week for MR mDixon-Quant examination.After the examination completed,liver and heart blood samples were col-lected simultaneously through laparotomy.The liver MR parameters,liver index,liver function,biochemistry,blood lipids and other indicators of each group of rats were measured.The pathological changes of rats by HE staining were observed.Fatty liver was classified according to histopathology,and statistical analysis based on clinical biochemical and imaging indicators was conducted.Results:A total of 49 rats(model group n=39,control group n=10)were successfully subjected to MR exami-nation,with a success rate of 98%(49/50).In the serological test results,AST,ALT,TG,TC,and LDL-C in the fatty liver group were positively correlated with the degree of liver steatosis,and the differences between the groups were statistically sig-nificant(P<0.05).HDL-C was negatively correlated with the degree of hepatic steatosis,and the difference between groups was statistically significant(P<0.05).In the MRI measurement results,HFF and R2* gradually increased as the degree of hepatic steatosis deepens.There was high correlation between HFF and fatty liver grading(r=0.809,P<0.05),and weak correlation be-tween R2* and fatty liver grading(r=0.409,P<0.05).Conclusion:MR mDixon-Quant technology has high accuracy in quantita-tively evaluating the fat content of MAFLD liver and has certain value in assessing iron deposition in MAFLD liver.关键词
脂肪肝/大鼠/磁共振成像Key words
Fatty Liver/Rats/Magnetic Resonance Imaging分类
医药卫生引用本文复制引用
王国光,孟令平,胡明秀,杨海生,官兵..磁共振mDixon-Quant技术联合肝生化指标对MAFLD脂肪定量及肝脏功能评估研究[J].中国临床医学影像杂志,2025,36(2):109-112,116,5.基金项目
上海健康医学院校级科研项目(自然一般,SSF-23-25-001). （自然一般,SSF-23-25-001）
