中国临床医学影像杂志2025，Vol.36Issue(2)：121-126,136,7.DOI:10.12117/jccmi.2025.02.011
双能CT定量参数术前预测上皮性卵巢癌分型的价值研究
Value of dual-energy CT quantitative parameters in preoperative prediction of epithelial ovarian cancer types
董德硕 1刘爱连 1宋庆玲 1刘义军1
作者信息
- 1. 大连医科大学附属第一医院放射科,辽宁 大连 116011
- 折叠
摘要
Abstract
Objective:To explore the value of dual-energy CT quantitative parameters in preoperative prediction of epithelial ovarian cancer(EOC)types.Materials and Methods:The data of 113 patients with EOC(35 patients with type Ⅰand 78 patients with type Ⅱ)who underwent dual-energy CT scan before surgery were retrospectively analyzed.The clinical features and FIGO staging were recorded.CT values of individual energy levels of 40～70 keV(interval 10 keV)were measured independently by two observers,and standardized iodine concentrations(AP-NIC,VP-NIC,DP-NIC)and extracellular volume fraction(ECV)in enhanced arterial,venous and delayed phases were calculated.The intra-group correlation coefficient(ICC)was used to compare the agreement of two observers.Independent sample t test or Mann-Whitney U test were used to compare the above parameters between the two groups.Multivariate Logistic regression analysis was used to find independent risk predictors.Area under the curve(AUC),sensitivity,and specificity were used to evaluate the diagnostic efficacy of univariate and combined models.The DeLong test was used to compare AUC differences between univariate and federated models.Results:The age of patients in type Ⅱ EOC group was significantly higher than those in type Ⅰ EOC group,CA125 and HE4 were significantly higher than that in type Ⅰ EOC group,while CA199 was lower than that in type Ⅰ EOC group(P<0.001).Most patients with type Ⅰ EOC had FIGO stage Ⅰ～Ⅱ,and most patients with type Ⅱ EOC had FIGO stage Ⅲ～Ⅳ,with statistically significant differences between the two groups(P<0.001).All parameters of dual-energy CT had good inter-observer consistency(ICC>0.75).The CT value of 40～70 keV(except AP-60 keV and AP-70 keV),AP-NIC,VP-NIC,DP-NIC and ECV in phase Ⅲ EOC group were significantly higher than those in type Ⅰ EOC group(P<0.05),while there was no statistical difference between AP-60 keV and AP-70 keV between the two groups.Age and VP-NIC were independent risk predictors for preoperative EOC classification.The AUC of age,VP-NIC and combined model were 0.759,0.788 and 0.862,respectively.The diagnostic efficiency of combined model was significantly different from that of single factor(P<0.05).Conclusion:Dual-energy CT quantitative parameters combined with clinical indicators can noninvasively predict EOC classification before surgery,in which age and VP-NIC were independent risk predictors.关键词
卵巢肿瘤/体层摄影术,X线计算机Key words
Ovarian Neoplasms/Tomography,X-Ray Computed分类
临床医学引用本文复制引用
董德硕,刘爱连,宋庆玲,刘义军..双能CT定量参数术前预测上皮性卵巢癌分型的价值研究[J].中国临床医学影像杂志,2025,36(2):121-126,136,7.
