中国临床药学杂志2025，Vol.34Issue(1)：10-15,6.DOI:10.19577/j.1007-4406.2025.01.002
基于欧洲医药保健网分类系统的药物治疗管理对围绝经期综合征患者的应用效果
Effectiveness of medication therapy management for patients with climacteric syndrome based on the Pharmaceutical Care Network Europe classification system
摘要
Abstract
AIM To investigate the efficacy of the Pharmaceutical Care Network Europe(PCNE)classification system in medication therapy management(MTM)for women with climacteric syndrome.METHODS From September 2021 to March 2022,118 outpatients with climacteric syndrome were recruited and divided into control group(n=53)and intervention group(n=65),according to their treatment preference.The control group was given conventional hormone replacement therapy(HRT)and clinical pharmacist medication guidance.In addition to the treatment received by the control group,the study group was provided with MTM based on the PCNE classification system.The drug-related problems(DRPs)in both groups were identified and analyzed according to the PCNE classification system.However,interventions for DRPs were only implemented in the study group.While types and causes of DRPs were discriminatory analyzed in 2 groups,pharmaceutical interventions about DRPs in the intervention group were carried out and taken notes.The Morisky Adherence Scale and the modified Kupperman index were used to assess medication adherence and the improvement of climacteric syndrome symptoms after 1,3,and 12 months of intervention,respectively.The duration of HRT in 2 groups was also compared.RESULTS The intervention group showed significantly higher medication compliance at 3 and 12 months and better treatment outcomes at 1,3,and 12 months(P＜0.05).The duration of HRT in the intervention group exceeded that in the control group(P＜0.05).During the intervention period,the intervention group demonstrated a significantly lower incidence of DRPs than the control group(P＜0.05).Approximately 88.09％of the intervention measures suggested by clinical pharmacists were fully or partially accepted by physicians and patients,leading to the successful resolution or partial resolution of about 86.05％of DRPs.CONCLUSION MTM based on the PCNE classification system could enhance medication adherence in patients with climacteric syndrome,optimize the effectiveness of HRT,mitigate the occurrence of DRPs,and effectively address any DRPs that may arise during treatment to ensure patient safety and therapeutic efficacy.关键词
围绝经期综合征/药物治疗管理/激素替代治疗/欧洲医药保健网分类系统Key words
climacteric syndrome/medication therapy management/hormone replacement therapy/PCNE classification system分类
药学引用本文复制引用
王东亮,宁颖,李寿林,李赛,尤一雯..基于欧洲医药保健网分类系统的药物治疗管理对围绝经期综合征患者的应用效果[J].中国临床药学杂志,2025,34(1):10-15,6.基金项目
江苏省药学会-恒瑞医院药学基金科研项目(编号H202054) （编号H202054）
