中国临床药学杂志2025，Vol.34Issue(1)：16-22,7.DOI:10.19577/j.1007-4406.2025.01.003
骨科抗菌药物一体化闭环药学服务模式的应用效果
Practice of rational usage of orthopedic antimicrobial drugs based on integrated closed-loop pharmacy service
摘要
Abstract
AIM To explore the impact of the integrated closed-loop pharmacy service model for antimicrobial drugs on improving rational drug use in orthopedics.METHODS A closed-loop pharmacy service model for orthopedic antibacterial drugs was established,integrating the pre-event,in-event,and post-event stages.Data on the usage of orthopedic antimicrobial drugs and physician orders were collected both before(2020)and after(January 2021-December 2023)the implementation.Indicators such as drug use intensity and rational drug use metrics,including irrational orders,antimicrobial drug use frequency,pre-use testing rates,usage rates,average costs,and acceptance of intervention suggestions,were compared before and after the implementation.RESULTS From 2021 to 2023,pharmacists reviewed a total of 109 756 medical prescriptions,and retorted 24 472 medical prescriptions,reducing 4 520 instances of antimicrobial drug use.The number of prescriptions for which intervention suggestions were proposed by pharmacists showed an increasing trend over the years.The defined daily doses of antimicrobial drug in the orthopedic department of the hospital had been decreasing,from 33.8 per hundred people per day in 2020 to 32.0 per 100 people per day in 2023.The indicators of rational drug usage were continuously improved,specifically the percentage of prophylactic use of antimicrobial drugs for Class Ⅰ incisions from 65.1％in 2020 to 22.4％in 2023.CONCLUSION The integrated closed-loop pharmacy service has been promoted to decrease the use of antibiotics practices and rationalize the use of orthopedic antimicrobial drugs.关键词
抗菌药物/审方/合理用药/一体化用药决策/骨科Key words
antimicrobial drugs/prescription review/drug rational usage/integrated medication decision/orthopedics分类
药学引用本文复制引用
杜沛龙,干润,屠祎惺,辛博,陈燕,韩冷,张剑萍,郭澄,杨全军..骨科抗菌药物一体化闭环药学服务模式的应用效果[J].中国临床药学杂志,2025,34(1):16-22,7.基金项目
上海市浦江人才(编号21PJ1411900) （编号21PJ1411900）
上海市第六人民医院院级管理类科研基金(编号X-4221) （编号X-4221）
上海市第六人民医院医疗服务能级提升工程医政管理优化项目(编号X-4108) （编号X-4108）
