中国临床药学杂志2025，Vol.34Issue(1)：39-44,6.DOI:10.19577/j.1007-4406.2025.01.007
抗癫痫发作药物促使癫痫共病抑郁的影响因素研究
Use of anti-seizure medications links to an increased risk of comorbid depression in patients with epilepsy
摘要
Abstract
AIM To investigate the independent risk factors of anti-seizure medication use contributing to the condition of comorbid depression in patients with epilepsy.METHODS A total of 308 epilepsy patients diagnosed between February 2018 and June 2022 were recruited in the study.According to the 17-item Hamilton Depression Rating Scale(HAMD-17),patients were categorized into the depression group(HAMD-17 score ≥ 7,n=115)and non-depression group(HAMD-17 score＜7,n=193).Demographic data,seizure-associated variables,and types of ASMs used were prospectively collected from the recruited patients.Depression was assessed using the HAMD-17.In addition,the Pittsburgh Sleep Quality Index(PSQI)and Epworth Sleepiness Scale(ESS)were used to evaluate subjective sleep quality and daytime sleepiness.Additionally,the binary logistic regression analyses were conducted to determine the influencing factors of comorbid depression due to ASMs.RESULTS The percentages of patients with benzodiazepine use,polytherapy of ASMs and poor sleep quality and seizure frequency in the last year were all significantly higher in the depression group compared to the non-depression group(P＜0.05).The proportion of patients using multiple ASMs,benzodiazepines,and those with poor sleep quality remained significantly higher in the depression group compared to the non-depression group after adjusting for potential confounding factors.The binary logistic regression analysis showed that polytherapy(OR=2.56,95％CI l.46-4.48,P=0.001)and poor sleep quality(OR=9.01,95％CI 4.77-16.99,P＜0.001)were independent risk factors for ASMs contributing to depression in patients with epilepsy.CONCLUSION Polytherapy of ASMs(especially containing benzodiazepine)and poor sleep quality are independent risk factors for comorbid depression in patients with epilepsy.In clinical practice,it is crucial to focus on screening and diagnosing emotional disorders during the treatment process for the patients.关键词
癫痫/抗癫痫发作药物/抑郁/共病/睡眠障碍Key words
epilepsy/anti-seizure medication/depression/comorbidity/sleep disturbances分类
药学引用本文复制引用
胡子寒,邵志海,彭伟锋..抗癫痫发作药物促使癫痫共病抑郁的影响因素研究[J].中国临床药学杂志,2025,34(1):39-44,6.基金项目
福建省卫健委科技计划项目(编号2021GGB033) （编号2021GGB033）
