中国临床药学杂志2025，Vol.34Issue(1)：51-55,5.DOI:10.19577/j.1007-4406.2025.01.009
盐酸氨溴索联合头孢哌酮钠舒巴坦钠对社区获得性肺炎老年患者的疗效
Efficacy of ambroxol hydrochloride combined with cefoperazone sodium and sulbactam sodium in elderly patients with community-acquired pneumonia
徐洁 1金海欧 1孙锦秀1
作者信息
- 1. 江苏省如皋市人民医院药剂科,南通 226500
- 折叠
摘要
Abstract
AIM To analyze the efficacy of ambroxol hydrochloride combined with cefoperazone sodium and sulbactam sodium in the treatment of elderly community-acquired pneumonia patients.METHODS Eighty elderly patients with community-acquired pneumonia were randomly separated into the conventional group(n=40)and combined group(n=40).The conventional group received treatment with cefoperazone sodium and sulbactam sodium,while the combined group received treatment with ambroxol hydrochloride combined with cefoperazone sodium and sulbactam sodium.Both groups underwent continuous treatment for 7 days.The efficacy,changes in lung function,serum S1PR3 level,and adverse reactions were compared between the 2 groups.RESULTS After treatment,the total effective rate of the combined group was higher than the conventional group(P＜0.05).After treatment,the disappearance time of fever,sputum,and lung rales in the combined group was earlier than that in the conventional group(P＜0.05).The highest respiratory flow rate(PEF),forced vital capacity(FVC),and maximum expiratory volume in the first second(FEV1)were all higher than those in the conventional group(P＜0.05).The serum S1PR3 level was lower than that in the conventional group(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between 2 groups(P＞0.05).CONCLUSION Ambroxol hydrochloride combined with cefoperazone sodium and sulbactam sodium has shown a more prominent effect than the simple use of cefoperazone sulbactam sodium.It has an obvious effect on symptom relief,and lung function improvement,and could further reduce the serum S1PR3 level in elderly community-acquired pneumonia patients with a good safety profile.关键词
盐酸氨溴索/头孢哌酮钠舒巴坦钠/社区获得性肺炎/肺功能/1-磷酸鞘氨醇受体3Key words
ambroxol hydrochloride/cefoperazone sulbactam sodium/community acquired pneumonia/lung function/sphingosine 1-phosphate receptor 3分类
药学引用本文复制引用
徐洁,金海欧,孙锦秀..盐酸氨溴索联合头孢哌酮钠舒巴坦钠对社区获得性肺炎老年患者的疗效[J].中国临床药学杂志,2025,34(1):51-55,5.
