中国临床医学2025，Vol.32Issue(1)：24-29,6.DOI:10.12025/j.issn.1008-6358.2025.20250019
钇-90树脂微球选择性内放射治疗肝脏恶性肿瘤的安全性分析
Safety analysis of Yttrium-90 resin microsphere selective internal radiation therapy on malignant liver tumors
摘要
Abstract
Objective To explore the safety of Yttrium-90 resin microsphere selective internal radiation therapy(90Y-SIRT)on malignant liver tumors.Methods A retrospective analysis was conducted on 64 patients with malignant liver tumors who underwent 90Y-SIRT from February 2023 to November 2024 at Weifang People's Hospital.The clinical characteristics of the patients and the occurrence of adverse reactions after treatment were analyzed to assess the safety of 90Y-SIRT.Results Among the 64 patients,there were 52 males(81.25%)and 12 females(18.75%);the average age was(56.29±11.08)years.Seven patients(10.94%)had tumors with maximum diameter of less than 5 cm,38 patients(59.38%)had tumors with maximum diameter of 5-10 cm,and 19 patients(29.68%)had tumors with maximum diameter of greater than 10 cm.There were 47 cases(73.44%)of solitary lesions and 17 cases(26.56%)of multiple lesions;53 cases(82.81%)were primary liver cancers and 11 cases(17.19%)were metastatic liver cancers.Of the 64 patients,63 successfully completed the Technetium-99m macroaggregated albumin(99mTc-MAA)perfusion test and received the 90Y-SIRT;one patient received 90Y-SIRT after the second 99mTc-MAA perfusion test due to a work error.The most common adverse reactions included grade 1 alanine aminotransferase(ALT)elevation in 26 cases(40.62%)and grade 2 in 2 cases(9.37%),grade 1 aspartate aminotransferase(AST)elevation in 27 cases(42.18%)and grade 2 in 7 cases(10.93%);grade 1 nausea in 17 cases(26.56%)and grade 2 in 6 cases(9.37%);grade 1 abdominal pain in 12 cases(18.75%),grade 2 in 5 cases(7.81%),and grade 3 in 1 case(1.56%);grade 1 vomiting in 11 cases(17.18%),grade 2 in 5 cases(7.81%),and grade 3 in 1 case(1.56%).Conclusion The adverse reactions of 90Y-SIRT for treating malignant liver tumors are mild,indicating good safety.关键词
钇-90/选择性内放射治疗/肝脏恶性肿瘤/安全性Key words
Yttrium-90/selective internal radiation therapy/malignant liver tumor/safety分类
临床医学引用本文复制引用
蔡佳,李文军,张海彬,王冠武,唐世伟,李荣丽,孔铭新,丁洪燕,原晓峰,胡玉莹,刘瑞梅,朱晓燕..钇-90树脂微球选择性内放射治疗肝脏恶性肿瘤的安全性分析[J].中国临床医学,2025,32(1):24-29,6.基金项目
潍坊市卫生健康委科研项目(WFWSJK-2021-185).Supported by Weifang Municipal Health Commission Research Project(WFWSJK-2021-185). （WFWSJK-2021-185）
