中国临床医学2025，Vol.32Issue(1)：85-92,8.DOI:10.12025/j.issn.1008-6358.2025.20241118
地舒单抗治疗骨折高风险绝经后骨质疏松症的疗效评价
Efficacy evaluation of denosumab in the treatment of patients with postmenopausal osteoporosis at high risk of fracture
摘要
Abstract
Objective To explore the difference of efficacy and safety between denosumab and zoledronic acid in the treatment of patients with postmenopausal osteoporosis(PMOP),and to optimize the medication regimen for PMOP patients.Methods A total of 123 PMOP patients with high risk of fracture at the Second Affiliated Hospital of Naval Medical University from September 2021 to March 2024 were selected and randomly divided into two groups:the denosumab group(n=63)and the zoledronic acid group(n=60).Both groups underwent one-year treatment and follow-up,bone metabolism indexes,lumbar vertebrae,femoral neck,and total hip bone mineral density(BMD)were monitored,and any adverse reactions were documented.Results After treatment,the lumbar vertebrae and total hip BMD of patients in the denosumab group and the zoledronic acid group were significantly improved(P＜0.05);the femoral neck BMD of patients in the zoledronic acid group was also significantly improved(P＜0.05).The improvement of lumbar vertebrae BMD in the denosumab group was significantly better than that in the zoledronic acid group,while the improvement of femoral neck and total hip BMD in the zoledronic acid group was significantly better than that in the denosumab group(P＜0.05).Bone metabolism indicators were significantly improved in both groups(P＜0.05),and no significant liver and kidney dysfunction were observed.A total of 7 patients in the zoledronic acid group had mild adverse reactions and 5 patients in the denosumab group had mild adverse reactions.Conclusions Denosumab significantly increased lumbar vertebrae BMD and improved bone metabolism markers in PMOP patients,thus reducing risk of fracture and demonstrating good safety.关键词
骨折高风险/绝经后骨质疏松症/地舒单抗/唑来膦酸Key words
high risk of fracture/postmenopausal osteoporosis/denosumab/zoledronic acid分类
医药卫生引用本文复制引用
周婧,侯幸赟,刘婷婷,郑骄阳..地舒单抗治疗骨折高风险绝经后骨质疏松症的疗效评价[J].中国临床医学,2025,32(1):85-92,8.基金项目
上海市卫生健康委员会面上项目(202140311).Supported by General Project of Shanghai Municipal Health Commission(202140311). （202140311）
