中国临床医学2025，Vol.32Issue(1)：108-113,6.DOI:10.12025/j.issn.1008-6358.2025.20241120
T1～2N0M0期十二指肠神经内分泌肿瘤患者内镜治疗与手术治疗的生存差异
Survival differences between endoscopic treatment and surgical treatment for patients with T1-2N0M0 duodenal neuroendocrine tumor
摘要
Abstract
Objective To compare the long-term survival outcomes of patients with T1-2N0M0 duodenal neuroendocrine tumor(DNET)after endoscopic resection(ER)or surgical resection(SR).Methods Patients diagnosed with T1-2N0M0 DNET between January 1,2004,and December 31,2015,were extracted from the SEER database.Kaplan-Meier survival curve and log-rank test were used to compare overall survival(OS)rate and cancer-specific survival(CSS)rate between patients undergoing ER or SR.Propensity score matching(PSM)was used to reduce grouping differences,and multivariate Cox regression was used to analyze factors affecting OS and CSS before and after PSM.Results A total of 656 patients were included,with 457 in ER group and 199 in SR group.Before PSM,there was no significant difference in the 5-year OS rate between the ER and SR groups(88.9%vs 89.6%),but there was a significant difference in the 5-year CSS rate(99.3%vs 96.9%,P=0.017).Before PSM,multivariate Cox regression analysis showed advanced age was an independent risk factor for decreased OS(P＜0.001).After PSM,there was no significant difference between the ER group(n=187)and SR group(n=187)in 5-year OS rate(90.2%vs 88.9%)or CSS rate(98.9%vs 96.7%).After PSM,multivariate Cox regression also showed advanced age was an independent risk factor for decreased OS,while resection method was not an independent factor for OS or CSS.Conclusions There is no significant difference in OS or CSS after endoscopic treatment and surgical treatments for patients with T1-2N0M0 DNET,and advanced age is an independent factor for OS.关键词
十二指肠神经内分泌肿瘤/内镜治疗/手术治疗/SEER数据库/生存Key words
duodenal neuroendocrine tumor/endoscopic treatment/surgical treatment/SEER database/survival分类
医药卫生引用本文复制引用
白斌,苏显,辛海贝,张敏峰,肖华,蔡慧..T1～2N0M0期十二指肠神经内分泌肿瘤患者内镜治疗与手术治疗的生存差异[J].中国临床医学,2025,32(1):108-113,6.基金项目
上海市宝山区科学技术委员会科技创新专项资金项目(2023-E-19),上海市浦东新区卫生健康委员会面上项目(PW2021A-28),上海中医药大学附属第七人民医院"启明星"人才培养计划项目(QMX2021-01).Supported by Science and Technology Innovation Special Fund Project of Shanghai Baoshan District Science and Technology Committee(2023-E-19),General Project of Shanghai Pudong New Area Health Commission(PW2021A-28),and Talents Training Program of Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine(QMX2021-01). （2023-E-19）
