中国临床医学2025，Vol.32Issue(1)：125-134,10.DOI:10.12025/j.issn.1008-6358.2025.20241030
丝氨酸羟甲基转移酶抑制剂在肿瘤治疗中的研究进展
Research progress of serine hydroxymethyltransferase inhibitors in tumor treatment
摘要
Abstract
Tumor is the result of long-term and unlimited proliferation of cells.Tumor cells adjust various metabolic fluxes to meet increased bioenergy and biosynthetic requirements.Serine is one of the eight non-essential amino acids in the human body.It plays an important role in a variety of physiological activities and can provide one carbon unit,glycine,etc.for cell proliferation.Serine hydroxymethyltransferase(SHMT)is a key enzyme that catalyzes the conversion of glycine and serine.It is highly expressed in a variety of tumors and is a potential target for anti-tumor drugs.This article focuses on the potential of SHMT as a new target for cancer treatment and the preliminary application of its inhibitors in preclinical studies of tumors,providing reference for the development of new targeted drugs for tumors.关键词
肿瘤/丝氨酸代谢/丝氨酸羟甲基转移酶抑制剂Key words
tumor/serine metabolism/serine hydroxymethyltransferase inhibitor分类
医药卫生引用本文复制引用
陈宜利,王培森,陈昱灵,曾园园..丝氨酸羟甲基转移酶抑制剂在肿瘤治疗中的研究进展[J].中国临床医学,2025,32(1):125-134,10.基金项目
国家自然科学基金(82272648),江苏省高等学校自然科学研究项目(22KJB320006).Supported by National Natural Science Foundation of China(82272648),The Natural Science Foundation of the Jiangsu Higher Education Institutions of China(22KJB320006). （82272648）
