中国临床医学2025，Vol.32Issue(1)：140-144,5.DOI:10.12025/j.issn.1008-6358.2025.20240434
双免疫检查点抑制剂联合安罗替尼治疗腺泡状软组织肉瘤1例报告
Dual immune checkpoint inhibitors combined with anlotinib in the treatment of alveolar soft part sarcoma:a case report
方杏华 1李伟 2周宇红2
作者信息
- 1. 上海市吴淞中心医院肿瘤科,上海 200940
- 2. 复旦大学附属中山医院肿瘤科,上海 200032
- 折叠
摘要
Abstract
Clinical data of a patient with alveolar soft part sarcoma(ASPS)treated at Zhongshan Hospital,Fudan University were retrospectively analyzed.The patient was initially diagnosed with abdominal ASPS with multiple lung metastases.After 6 weeks of treatment with nivolumab and ipilimumab,the patient achieved stable disease(SD).In the 7th week,the treatment was changed to a combination of nivolumab(30 mg,d1,q3w),anlotinib(8 mg,d1-14,q3w)and ipilimumab(50 mg,d1,q6w).The patient remained SD at the 12th week.The patient then underwent iliac artery embolization and intensity-modulated radiation therapy for the lesion in the psoas major muscle,while continuing the combination treatment.By the 24th week,the evaluation showed partial remission(PR)of both primary tumor and lung metastases.The patient experienced mild adverse reactions during treatment.关键词
腺泡状软组织肉瘤/免疫检查点抑制剂/血管抑制剂Key words
alveolar soft part sarcoma/immune checkpoint inhibitor/vascular inhibitor分类
临床医学引用本文复制引用
方杏华,李伟,周宇红..双免疫检查点抑制剂联合安罗替尼治疗腺泡状软组织肉瘤1例报告[J].中国临床医学,2025,32(1):140-144,5.
