中国药科大学学报2025，Vol.56Issue(1)：22-30,9.DOI:10.11665/j.issn.1000-5048.2024012001
中药挥发油化学成分和抗抑郁作用机制研究进展
Research progress on the chemical composition and antidepressant mechanism of volatile oils of traditional Chinese medicine
张一飞 1程露 1任明诗 1郭焘 2匡凤姣 2康宗华 2罗建光 1吴斐华1
作者信息
- 1. 中国药科大学中药学院,南京 211198
- 2. 海南华创槟榔研究院,海口 570208
- 折叠
摘要
Abstract
Depressive disorder is a mental illness characterized by poor mood and cognitive dysfunction caused by a range of complicated factors.Antidepressants have strong short-term efficacy in clinical application,yet with significant adverse effects and resistance in long-term use.Essential oils are small molecular compounds mainly composed of monoterpenes and sesquiterpenes,most of which are characterized by aromatic odors,easy permeability through the blood-brain barrier,and low toxic side effects.Volatile oil from traditional Chinese medicine can regulate neurotransmitter monoamine,hypothalamic-pituitary-adrenal axis,brain-derived neurotrophic factor,neuroinflammation and oxidative stress,and intestinal microbiota-gut-brain axis to exert an antidepressant effect through multiple pathways and targets.This review summarizes the main antidepressant chemical components of essential oil of traditional Chinese medicine,their pharmacological mechanisms and clinical application,aiming to provide some reference for further development and clinical application of essential oil of traditional Chinese medicine.关键词
挥发油/抗抑郁/活性成分/作用机制Key words
volatile oil/antidepressant/active ingredient/mechanism of action分类
中医学引用本文复制引用
张一飞,程露,任明诗,郭焘,匡凤姣,康宗华,罗建光,吴斐华..中药挥发油化学成分和抗抑郁作用机制研究进展[J].中国药科大学学报,2025,56(1):22-30,9.
