中国药科大学学报2025，Vol.56Issue(1)：31-39,9.DOI:10.11665/j.issn.1000-5048.2024030103
代谢功能障碍相关脂肪性肝病中蛋白乙酰化修饰的研究进展
Research progress of acetylation in the pathogenesis of MASLD
摘要
Abstract
Metabolic dysfunction-associated steatotic liver disease(MASLD)is the most prevalent cause of chronic liver disease worldwide,and its intricate pathogenesis presents challenges in the development of new drugs.As a common way of post-translational modification,acetylation regulates protein stability,enzyme activity,and subcellular localization,occurring extensively in MASLD-associated processes such as lipid metabolism,inflammatory response,and oxidative stress.In this paper,we comprehensively review the mechanism of acetylation in MASLD,analyze the expression levels of acetylases in liver tissues of MASLD patients from the gene expression omnibus(GEO),discuss the changes in relevant enzyme expression and mechanisms in animal models,and further explore the feasibility of targeting acetylation for MASLD treatment,in the hope of offering a new perspective for advancing drug discovery in the field of MASLD.关键词
代谢功能障碍相关脂肪性肝病/代谢功能障碍相关脂肪性肝炎/乙酰化/乙酰化酶Key words
metabolic dysfunction-associated steatotic liver disease/metabolic dysfunction-associated steatohepatitis/acetylation/acetylase分类
药学引用本文复制引用
颜利,居峰禹,沈新,于烨,王文辉..代谢功能障碍相关脂肪性肝病中蛋白乙酰化修饰的研究进展[J].中国药科大学学报,2025,56(1):31-39,9.基金项目
This study was supported by the National Natural Science Foundation of China(No.81902480)and Hunan Provincial"Huxiang"High-level Talent Gathering Project(2021RC5013) 国家自然科学基金项目(No.81902480) （No.81902480）
湖南省"湖湘"高层次人才聚集工程项目(2021RC5013) （2021RC5013）
