中国药科大学学报2025，Vol.56Issue(1)：40-48,9.DOI:10.11665/j.issn.1000-5048.2024072101
三类基于香豆素母核衍生物的合成及其抗炎活性
Synthesis and anti-inflammatory activity of three series of coumarin-based derivatives
摘要
Abstract
In this work,starting from 4-hydroxycoumarin,three series of 22 coumarin derivatives,among which 8 have not been reported in the literature,were synthesized and their in vitro anti-inflammatory activities and mechanisms of action were preliminarily investigated using mouse macrophage model.The results showed that most of the derivatives could significantly inhibit the production of pro-inflammatory factor NO,with compounds 2e,2f,2g,2h,2i,2j,4e,and 4f showing better anti-inflammatory activity than the positive control drug dexamethasone.Further experiments showed that compounds 2h and 4f significantly inhibited the production of pro-inflammatory factors IL-6,TNF-α and IL-1β in RAW264.7 macrophages,and could,therefore,be used as lead compounds for further studies.关键词
香豆素衍生物/合成/抗炎活性Key words
coumarin derivatives/synthesis/anti-inflammatory activity分类
药学引用本文复制引用
赵秀娟,杨恒俐,吴金叶,郑晓琦,张耀苹,林玉萍,虎春艳..三类基于香豆素母核衍生物的合成及其抗炎活性[J].中国药科大学学报,2025,56(1):40-48,9.基金项目
This study was supported by the Applied Basic Research Joint Special Funds of Yunnan Provincial Science and Technology Department and Yunnan University of Chinese Medicine(202301AZ070001-061) 云南省科学技术厅-云南中医药大学应用基础研究联合专项资助项目(202301AZ070001-061) （202301AZ070001-061）
