中国药科大学学报2025，Vol.56Issue(1)：49-55,7.DOI:10.11665/j.issn.1000-5048.2024072601
透明质酸接枝双氯芬酸的制备、表征和体外释放
Preparation,characterization and in vitro release of diclofenac grafted with hyaluronic acid
摘要
Abstract
In reference to the original drug diclofenac etalhyaluronate sodium(DF-HA),a graft copolymer was synthesized by covalent bonding.The structure of DF-HA was characterized by 1H NMR,UV-Vis spectrophotometry and FT-IR.The results showed that DF-HA was successfully synthesized,and the grafting rate was determined to be approximately 17%by 1H NMR and UV-Vis spectrophotometry.The in vitro release of DF-HA graft copolymer was studied by HPLC,and its release of diclofenac(DF)in phosphate buffered saline(PBS,pH 7.4)was investigated.The drug release rate of free DF was 83.6%after 6 h,and that of DF-HA was 4.8%within 1 d and 17.7%within 21 d,which were basically consistent with the release behavior of the reference listed drug.DF-HA could significantly achieve the sustained release of DF,and high molecular weight hyaluronic acid itself had the effect of treating osteoarthritis.With both advantages,DF-HA could have good application value.关键词
透明质酸/双氯芬酸钠/接枝共聚物/表征/体外释放Key words
hyaluronic acid/diclofenac sodium/graft copolymer/characterization/in vitro release分类
药学引用本文复制引用
宋琳琪,郑枫..透明质酸接枝双氯芬酸的制备、表征和体外释放[J].中国药科大学学报,2025,56(1):49-55,7.
