中国输血杂志2025，Vol.38Issue(2)：189-193,5.DOI:10.13303/j.cjbt.issn.1004-549x.2025.02.005
主动脉全弓置换术中自体富血小板血浆分离技术的有效性研究
Effectiveness of platelet-rich plasma separation technique in total aortic arch replacement
摘要
Abstract
Objective To evaluate the efficacy and practicality of autologous platelet-rich plasma(aPRP)in patients undergoing total aortic arch replacement for aortic dissection.Methods A retrospective analysis was performed on 483 pa-tients diagnosed with type A aortic dissection who underwent total aortic arch replacement between January 2016 and Novem-ber 2023.Patients were categorized into two groups based on whether they received aPRP.Baseline characteristics,intraop-erative blood product usage and postoperative outcomes were compared between the two groups.Results The aPRP group exhibited reduced usage of allogeneic platelets(1.55±1.04 vs 1.60±1.27)U,allogeneic plasma(480.89±432.49 vs 746.50±508.81)mL,allogeneic RBC(red blood cell)(5.95±1.91 vs 6.17±3.52)U,bivalirudin(2.66±1.51 vs 3.31±1.59)U and coagulation factor Ⅶ(0.67±1.03 vs 1.22±1.43)mg compared to the non-aPRP group(P<0.05).The inci-dence of postoperative hypoxemia was lower in the aPRP group(43.98%vs 48.41%),and the duration of mechanical ven-tilation was significantly shorter[median 50.91(interquartile range 18.71,113.71)vs 83.40(37.73,151.98)hours].There were no significant differences between the two groups in terms of postoperative mortality,continuous bedside hemofil-tration,cerebral infarction,cerebral hemorrhage,paraplegia or re-exploration for hemostasis(P>0.05).Conclusion The application of aPRP in total aortic arch replacement effectively diminishes intraoperative blood product usage and the inci-dence of lung injury-related complications.However,it does not demonstrate significant benefits in terms of mortality,cere-bral infarction and other complications.关键词
主动脉夹层/输血/富血小板血浆Key words
aortic dissection/blood transfusion/platelet-rich plasma分类
临床医学引用本文复制引用
庞超,张韶鹏,白云鹏,谢淑华..主动脉全弓置换术中自体富血小板血浆分离技术的有效性研究[J].中国输血杂志,2025,38(2):189-193,5.基金项目
天津市医学重点学科(专科)建设项目(TJYXZDXK-042A) （专科）
天津市应用基础研究重点项目(22JCYBJC01430) （22JCYBJC01430）
天津市科技计划项目(21JCZDJC00610) （21JCZDJC00610）
