中国输血杂志2025，Vol.38Issue(2)：209-213,221,6.DOI:10.13303/j.cjbt.issn.1004-549x.2025.02.008
健康供者造血干细胞的单采效率及安全性分析
Efficiency and safety of haematopoietic stem cell collection in healthy donors
何芮 1朱帮强 1闻慧琴 1王海婧 1卞茂红 1刁玉洁1
作者信息
- 1. 安徽医科大学第一附属医院 输血科,安徽 合肥 230022
- 折叠
摘要
Abstract
Objective To explore the key factors affecting the efficiency and safety of hematopoietic stem cell aphere-sis.Methods The clinical data of 59 healthy donors who underwent allogeneic hematopoietic stem cell donation in the First Affiliated Hospital of Anhui Medical University from January 2021 to June 2024 were retrospectively analyzed.The number of CD34+cells was used to evaluate the eligibility of stem cell collection.The effects of donor gender,age,patient weight,as well as the number of WBC,MNC,RBC,Hb,HCT,PLT,CD34+cells,CD34+percentage and instrument operating pa-rameters on collection efficiency were analyzed.Results A total of 59 donors were enrolled,and 68 occasions of stem cell apheresis were performed,with a qualified collection rate of 56%.Donor gender,age,patient weight,total blood circula-tion volume,anticoagulant dosage,collection time,calcium gluconate dosage and RBC,Hb,HCT levels were not signifi-cantly correlated with the collection effect(P>0.05).Multivariate logistic regression analysis showed that the number of MNC cells,CD34+cells and stem cell product volume were the key factors affecting the efficiency and safety.A total of 12 donors had mild adverse reactions during the collection process,and all of them were improved after treatment.Conclusion Optimizing apheresis strategy based on the three factors of MNC,WBC count and stem cell product volume on the day of collection will help to achieve high-quality collection and improve the success rate of transplantation.关键词
外周造血干细胞/CD34+细胞/单采效率Key words
peripheral blood hematopoietic stem cells/CD34+/apheresis efficiency分类
医药卫生引用本文复制引用
何芮,朱帮强,闻慧琴,王海婧,卞茂红,刁玉洁..健康供者造血干细胞的单采效率及安全性分析[J].中国输血杂志,2025,38(2):209-213,221,6.
