中国药科大学学报2025，Vol.56Issue(1)：125-131,7.DOI:10.11665/j.issn.1000-5048.2023112002
类泛素化修饰在2型糖尿病发生中的研究进展
Research progress on sumoylation in type 2 diabetes mellitus
摘要
Abstract
Sumoylation is a newly discovered post-translational modification,in which a small ubiquitin-like modifier(SUMO)is covalently conjugated to a lysine residue in a target protein.This provides an efficient way to modulate the activity,stability and subcellular localization of a wide variety of substrates.Sumoylation plays a key role in the occurrence and development of type 2 diabetes mellitus(T2DM).This paper addresses the relationship between sumoylation and T2DM in regulation of pancreatic β-cell function,the metabolic order in skeletal muscles,liver and other organs and diabetes-associated complications.A deeper knowledge of sumoylation may enable us to better understand the pathogenesis of T2DM and sumoylation system at the molecular level,which can help provide new ideas for the early diagnosis and subsequent treatment of T2DM and its associated complications.关键词
SUMO化修饰/2型糖尿病/胰岛β细胞/胰岛素抵抗/糖尿病并发症Key words
sumoylation/type 2 diabetes mellitus/pancreatic β-cell/insulin resistance/diabetes-associated complications分类
医药卫生引用本文复制引用
陈曦,金亮..类泛素化修饰在2型糖尿病发生中的研究进展[J].中国药科大学学报,2025,56(1):125-131,7.基金项目
This study was supported by the National Natural Science Foundation of China(No.82373925,No.82070801) 国家自然科学基金项目(No.82373925,No.82070801) （No.82373925,No.82070801）
