中国输血杂志2025，Vol.38Issue(2)：222-226,243,6.DOI:10.13303/j.cjbt.issn.1004-549x.2025.02.010
广州地区献血者人类嗜T淋巴细胞病毒流行情况调查
Prevalence of human T-lymphocyte leukemia virus among blood donors in Guangzhou
摘要
Abstract
Objective To analyze the prevalence of human T-lymphocyte leukemia virus(HTLV)among blood donors in Guangzhou from 2016 to 2021,and provide a basis for blood collection and supply management in this region.Methods A total of 2 116 951 voluntary blood donors were screened for anti-HTLV by enzyme-linked immunosorbent assay(ELISA)from March 2016 to December 2021 in Guangzhou,and the reactive cases were further confirmed by Western blotting(WB).Qualitative data were analyzed by χ2 with spss19 software.The trend of the total positive rate of HTLV confirmation test by WB from 2016 to 2021 was analyzed with the Joinpoint software,and the annual percent change(APC)was used to determine whether the trend changes were statistically significant.Results From March 2016 to December 2021,the total positive rate for anti-HTLV by ELISA among voluntary blood donors in Guangzhou was 0.019 7%(416/2116 951),and the WB confirmed positive rate was 0.001 1%(23/2 116 951).The total positive rate of HTLV among individual voluntary blood donors in the six main districts(0.002 12%,19/895 301)was higher than that among group voluntary blood donors(0.000 32%,3/951 947)(P<0.05).There was no significant difference in the total positive rate of HTLV confirmation between the six main districts(0.001 19%)and the three non-main districts(0.000 37%)(P>0.05).The trend of the total positive rate of HTLV infection in the six main districts and the Guangzhou area(including the six main districts and three non-main districts)showed no significant increase or decrease.Conclusion The prevalence of HTLV among blood donors in Guangzhou remains at a low level.关键词
人类嗜T淋巴细胞病毒/献血者/ELISA/蛋白印迹法/趋势分析Key words
human T-lymphocyte leukemia virus(HTLV)/blood donor/ELISA/Western blotting(WB)/trend analysis分类
临床医学引用本文复制引用
李玉笑,戎霞,何博,杜荣松,单振刚,廖峭..广州地区献血者人类嗜T淋巴细胞病毒流行情况调查[J].中国输血杂志,2025,38(2):222-226,243,6.基金项目
广州市科技计划项目(2023A03J1000) （2023A03J1000）
