中国医学工程2025，Vol.33Issue(2)：26-32,7.DOI:10.19338/j.issn.1672-2019.2025.02.005
着丝粒蛋白B表达水平与胶质瘤患者预后的相关性
Correlation between expression level of centromere protein B and prognosis of glioma patients
侯程山 1向井念 2付锐1
作者信息
- 1. 锦州医科大学,辽宁 锦州 121000
- 2. 湖北医药学院 临床学院,湖北 十堰 442000
- 折叠
摘要
Abstract
[Objective]To investigate the relationship between the expression of centromere protein B(CENPB)in glioma tissues and the prognosis of patients,and to analyze its biological role.[Methods]Based on The Cancer Genome Atlas(TCGA)database,Wilcoxon signed rank test was used to compare the expression level of CENPB in pancarcinoma,and its correlation with clinical characteristics and prognosis of glioma patients was further analyzed.Cox regression analysis and Kaplan-Meier survival curve were used to analyze the correlation between CENPB and glioma survival.The enrichment pathways of CENPB-associated genes were analyzed using the Gene Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG)database.Single sample gene enrichment analysis(ssGSEA)was used to analyze the correlation between immune infiltration and CENPB expression in glioma.[Results]Compared with normal tissues,CENPB gene was highly expressed in glioma tissues.The expression level of CENPB was higher in gliomas of grade Ⅳ(WHO grade),IDH wild type,and gliomas without 1p/19q co-deletion.ssGSEA showed that Th2 cell infiltration was positively correlated with CENPB expression in glioma.[Conclusion]CENPB is an independent risk factor for poor prognosis of glioma,and the regulation of CENPB expression may be a potential target for treatment of glioma.关键词
胶质瘤/着丝粒蛋白B/生物信息学Key words
glioma/centromere protein B/bioinformatics分类
医药卫生引用本文复制引用
侯程山,向井念,付锐..着丝粒蛋白B表达水平与胶质瘤患者预后的相关性[J].中国医学工程,2025,33(2):26-32,7.
