中国医学工程2025，Vol.33Issue(2)：44-48,5.DOI:10.19338/j.issn.1672-2019.2025.02.009
桥接治疗辅助血管内介入治疗对急性脑梗死的应用研究
Application of bridge therapy assisted with endovascular therapy in acute cerebral infarction
摘要
Abstract
[Objective]To observe the clinical effect of bridging therapy in assisting endovascular therapy(EVT)in acute cerebral infarction.[Methods]This study is a prospective study,and the study subjects were randomly selected from 105 cases of acute cerebral infarction admitted to the Affiliated Hospital of Yellow River University of Science and Technology from January 2022 to December 2023.The grouping method was computer randomization,and the enrolled patients were divided into the EVT group(52 cases)and the combination group(53 cases).The EVT group received EVT treatment directly,while the combination group received bridge therapy to assist EVT treatment.The vascular reperfusion,cerebral hemodynamic improvement,neurological function recovery,and prognosis of the two groups of patients were compared.[Results]Under different treatment regimens,the vascular recanalization rate in the combination group was 88.68%(47/53),higher than the EVT group[73.08%(38/52)](P<0.05).The cerebral blood flow(CBF)and cerebral blood volume(CBV)of the combination group were 50.23±10.31 mL/(100g⋅min)and 4.49±1.31 mL/100g,higher than the EVT group[45.25±10.44 mL/(100g⋅min)and 3.62±0.79 mL/100g];the hypoperfusion intensity ratio(HIR)in the combination group(0.36±0.11)was lower than the EVT group(0.76±0.25)(P<0.05).The values of NSE and S100β in the combination group were 8.61±1.46 ng/mL and 10.32±2.24 pg/mL,lower than the EVT group(10.66±2.39 ng/mL and 12.77±3.31 pg/mL)(P<0.05).The modified Rankin Scale(mRS)score of the combination group(3.44±0.45)was lower than the EVT group(4.25±1.72),and the modified Barthel index(MBI)score(86.23±10.25)was higher than the EVT group(81.18±10.27)(P<0.05).The incidence of poor prognosis in the combination group was 5.66%(3/53),lower than the EVT group[23.08%(12/52)](P<0.05).[Conclusion]Bridge therapy combined with EVT therapy can improve the vascular reperfusion rate of acute cerebral infarction,promote the recovery of cerebral hemodynamics and neurological function in patients,and reduce the risk of adverse prognosis.关键词
急性脑梗死/血管内介入治疗/桥接治疗/血管再通率/预后情况Key words
acute cerebral infarction/intravascular intervention therapy/bridging therapy/vascular recanalization rate/prognostic situation分类
医药卫生引用本文复制引用
张铁山,王冬梅,邢汝月,陈骏..桥接治疗辅助血管内介入治疗对急性脑梗死的应用研究[J].中国医学工程,2025,33(2):44-48,5.基金项目
河南省医学科技攻关项目(LHGJ20201215) （LHGJ20201215）
