摘要
Abstract
Objective:To explore the effect of nitric oxide inhalation(iNO)combined with high frequency oscillatory ventilation(HFOV)on neonates with persistent pulmonary hypertension(PPHN).Method:Clinical data of 80 children with PPHN admitted to Jiujiang Maternal and Child Health Hospital from January 2020 to December 2023 were retrospectively analyzed,and they were divided into two groups according to different treatment methods,with 40 cases in each group.The control group received HFOV treatment,and the observation group received iNO combined with HFOV treatment.The clinical efficacy,blood gas indexes,pulmonary artery parameters,left heart function and complications were compared between the two groups.Result:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in blood gas indexes,pulmonary artery parameters and left heart function between the two groups(P>0.05).After treatment,the arterial partial pressure of carbon dioxide(PaCO2),pulmonary artery diameter,pulmonary artery pressure(PAP)and myocardial work index(Tei index)in observation group were lower than those in control group,arterial oxygen partial pressure(PaO2),blood oxygen saturation(SaO2),left ventricular systolic peak velocity,left ventricular mitral ring diastolic peak velocity and left ventricular output were all higher than those of control group,the differences were statistically significant(P<0.05).The complication rate of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion:iNO combined with HFOV is effective in the treatment of PPHN children,it can adjust blood gas indexes and pulmonary artery parameters,improve left heart function and reduce complications.关键词
新生儿持续肺动脉高压/一氧化氮吸入/高频振荡通气/血气指标/肺动脉参数/左心功能/并发症Key words
Neonates with persistent pulmonary hypertension/Nitric oxide inhalation/High frequency oscillatory ventilation/Blood gas index/Pulmonary artery parameters/Left heart function/Complications
