中国医学工程2025，Vol.33Issue(2)：97-102,6.DOI:10.19338/j.issn.1672-2019.2025.02.020
肺曲霉病的危险因素及临床特征分析
Risk factors and clinical characterization of pulmonary aspergillosis
摘要
Abstract
[Objective]To explore the risk factors,clinical features,diagnosis,treatment and prognosis of patients with pulmonary aspergillosis,and to provide reference for early diagnosis and treatment of pulmonary aspergillosis.[Methods]General condition,risk factors,clinical features,lung imaging,bronchoscopy,treatment and regression of patients diagnosed with pulmonary aspergillosis from January 2018 to July 2023 in Xiangyang First People's Hospital were retrospectively analyzed.[Results]A total of 115 patients with pulmonary aspergillosis were collected,including 68 cases of invasive pulmonary aspergillosis(IPA)and 47 cases of chronic pulmonary aspergillosis(CPA),which were prevalent among the elderly,aged≥60 years 71 cases.Among risk factors,antimicrobials≥3 types of medications(50.4%),use of hormones(46.1%),prolonged smoking(34.8%),and immunosuppressant(32.2%)were common.CPA is prone to respiratory disease and IPA is prone to other systemic diseases,but both are susceptible to combined bacterial and viral infections and to progression to respiratory failure and sepsis.Clinical manifestations of pulmonary aspergillosis were not specific,the main manifestations of lung imaging for the two lungs were multiple foci of lesions,lamellar shadows,nodular shadows,cavitation shadows,of which cavitation shadows are more common in CPA.Tracheoscopy mainly showed mucosal congestion and oedema,tracheal stenosis as well as purulent secretions.GM test was the mainstay of laboratory tests.The treatment was based on triazoles as the first-line drugs,with an improvement rate of 62.6%,a mortality rate of 15.7%,a lapse rate of 13.0%,an inactivation rate of 6.1%,and a relapse rate of 3.5%after treatment.[Conclusion]Although the clinical features of pulmonary aspergillosis lack specificity,pulmonary aspergillosis infection needs to be considered in time for early diagnosis and treatment to improve the patient's prognosis when the patient has relevant manifestations,pulmonary imaging features,risk factors,and co-morbidities.关键词
曲霉菌/危险因素/临床特征Key words
aspergillus/risk factors/diagnostic trait分类
临床医学引用本文复制引用
黄明淋,李平,陈俊文..肺曲霉病的危险因素及临床特征分析[J].中国医学工程,2025,33(2):97-102,6.基金项目
北京白求恩公益基金项目(SCZ185BS) （SCZ185BS）
湖北省"323"攻坚行动襄阳市第一人民医院重点专项科研基金(XYY2022-323) （XYY2022-323）
