中国中医急症2025，Vol.34Issue(2)：302-306,5.DOI:10.3969/j.issn.1004-745X.2025.02.030
升阳通督针法联合补阳还五汤治疗急性缺血性脑卒中(气虚血瘀证)的临床观察
Clinical Study on Shengyang Tongdu Acupuncture Combined with Buyang Huanwu Decoction in the Treatment of Acute Ischemic Stroke(Syndrome of Blood Stasis due to Qi Deficiency)
摘要
Abstract
Objective:To evaluate the clinical efficacy and mechanism of Shengyang Tongdu acupuncture com-bined with Buyang Huanwu Decoction in treating patients with acute ischemic stroke(AIS)with syndrome of blood stasis due to qi deficiency.Methods:A total of 110 AIS patients were randomly divided into a control group and an observation group,each with 55 cases.Both groups received conventional integrated western medicine treat-ment.The control group took Buyang Huanwu Decoction orally,while the observation group additionally received Shengyang Tongdu acupuncture based on the control group's treatment.The treatment course lasted for 14 days.Clinical efficacy was compared between the two groups.NIHSS,BI,FMA,mRS,and syndrome of blood stasis due to qi deficiency scores were assessed.Levels of brain-derived neurotrophic factor(BDNF),endothelin-1(ET-1),tumor necrosis factor-alpha(TNF-α),nitric oxide(NO),C-reactive protein(CRP),interleukin-6(IL-6),calcitonin gene-related peptide(CGRP),IL-1β,and hemorheological indices were measured before and after treatment.Re-sults:After treatment,the overall effective rate of clinical efficacy in the observation group(89.09%)was higher than that in the control group(74.55%)(P<0.05).The NIHSS score in the observation group was lower than that in the control group(P<0.05).After treatment,the scores for major symptoms of syndrome of blood stasis due to qi deficiency(hemiplegia,facial paralysis,dysarthria,hemisensory disturbance,pale complexion,shortness of breath,and fatigue),total scores,and mRS scores in the observation group were lower than those in the control group(P<0.05),while BI and FMA scores were higher(P<0.05).Levels of BDNF,CGRP,and NO in the observa-tion group were higher than those in the control group,while levels of ET-1,TNF-α,CRP,IL-6,IL-1β,and hemorheological indices were lower(P<0.05).Conclusion:On the basis of conventional integrated Western medi-cine treatment,Shengyang Tongdu acupuncture combined with Buyang Huanwu Decoction can further reduce the degree of neurological deficits,improve motor function and activities of daily living,alleviate clinical symptoms,promote neurological recovery,and enhance clinical efficacy in treating AIS with syndrome of blood stasis due to qi deficiency.The mechanism may involve the inhibition of inflammatory responses,improvement of hemorheology,and regulation of vascular endothelial factors.关键词
急性缺血性脑卒中/气虚血瘀证/升阳通督针法/补阳还五汤/炎症反应/血液流变学Key words
Acute ischemic stroke/Syndrome of blood stasis due to qi deficiency/Shengyang Tongdu acupunc-ture/Buyang Huanwu Decoction/Inflammatory response/Hemorheology分类
医药卫生引用本文复制引用
赵伟,钱兴龙,刘宇驰,符昱..升阳通督针法联合补阳还五汤治疗急性缺血性脑卒中(气虚血瘀证)的临床观察[J].中国中医急症,2025,34(2):302-306,5.基金项目
江苏省中医药管理局科研项目(2023B0935) （2023B0935）
