中国医学创新2025，Vol.22Issue(6)：29-33,5.DOI:10.3969/j.issn.1674-4985.2025.06.007
疏肝止泻汤加减治疗腹泻型肠易激综合征的临床观察
Clinical Observation on Modified Shugan Zhixie Decoction in the Treatment of Diarrhea-predominant Irritable Bowel Syndrome
摘要
Abstract
Objective:To investigate the clinical effect and mechanism of modified Shugan Zhixie Decoction in the treatment of diarrhea-predominant irritable bowel syndrome.Method:A total of 80 patients with diarrhea-predominant irritable bowel syndrome in Henan Provincial Hospital of Traditional Chinese Medicine from January 2022 to June 2023 were divided into two groups with 40 cases in each group by the random number table.The control group was treated with Pinaverium Bromide,the observation group was treated with Pinaverium Bromide combined with modified Shugan Zhixie Decoction.Then the total effective rates of diarrhea-predominant irritable bowel syndrome treatment,recurrence rates,safety situation,blood indexes[cholecystokinin(CCK),neuropeptide Y(NPY),substance-P(SP),5-hydroxy tryptamine(5-HT),motilin(MOT)and vasoactine intrestinal peptide(VIP)],rectal sensitivity(rectal perception threshold and defecation threshold)and life qualify(IBS-QOL scale)before and after the treatment of two groups were compared.Result:The total effective rate of diarrhea-predominant irritable bowel syndrome treatment of observation group was significantly higher than that of control group,the recurrence rate was significantly lower than that of control group,the differences were statistically significant(P<0.05);the safety situation of two groups was compared,the difference was not statistically significant(P>0.05);the blood indexes,rectal sensitivity and IBS-QOL scale of two groups before the treatment were compared,the differences were not statistically significant(P>0.05),the serum CCK,SP,5-HT,MOT and VIP of observation group after the treatment were significantly lower than those of control group,the serum NPY,rectal sensitivity indexes and IBS-QOL scale scores were significantly higher than those of control group,the differences were statistically significant(P<0.05).Conclusion:The clinical effect of modified Shugan Zhixie Decoction in the treatment of diarrhea-predominant irritable bowel syndrome is better,and it may play role by improving the patient's blood indexes and rectal sensitivity,its safety is high too,so its application value in patients with diarrhea-predominant irritable bowel syndrome is higher.关键词
疏肝止泻汤加减/腹泻型肠易激综合征/安全性/作用机制Key words
Modified Shugan Zhixie Decoction/Diarrhea-predominant irritable bowel syndrome/Safety/Mechanism引用本文复制引用
聂山文,赵文霞,吴秀霞..疏肝止泻汤加减治疗腹泻型肠易激综合征的临床观察[J].中国医学创新,2025,22(6):29-33,5.基金项目
第七批全国老中医药专家学术经验继承项目(国家中医药人教函[2022]76号) （国家中医药人教函[2022]76号）
河南省中医药科学研究专项课题(2022ZY1077) （2022ZY1077）
