中国医药科学2025，Vol.15Issue(2)：12-15,4.DOI:10.20116/j.issn2095-0616.2025.02.03
中药基于NOD样受体热蛋白结构域相关蛋白3通路治疗溃疡性结肠炎的研究进展
Research progress of Chinese materia medica in the treatment of ulcerative colitis based on NOD-like receptor thermoprotein structural domain-associated protein 3 pathway
摘要
Abstract
Ulcerative colitis(UC)is a chronic disease,its clinical process is intermittent,characterized by remission and recurrence,and its etiology is unknown.At present,most of the research on its pathogenesis focuses on intestinal mucosal immune dysfunction.At present,western medicine is the main medical treatment for UC patients,but the overall effective rate needs to be improved,so the treatment scheme of Chinese materia medica has attracted much attention.Recent studies have confirmed that the therapeutic efficacy of Chinese materia medica for UC is obvious.A large number of research have investigated the function mechanism of Chinese materia medica in the treatment of UC by regulating the inflammatory corpuscle pathway of NOD-like receptor thermoprotein structural domain-associated protein 3(NLRP3).The results show that NLRP3 signaling pathway is the key target pathway of Chinese materia medica in the treatment of UC.In this paper,NLRP3 and ulcerative colitis as the starting point,the related literature of Chinese materia medica regulating NLRP3 inflammatory corpuscle signal pathway in recent years to treat UC is reviewed,and reference for the follow-up research is provided.关键词
NOD样受体热蛋白结构域相关蛋白3/中药/溃疡性结肠炎/综述Key words
NOD-like receptor thermoprotein structural domain-associated protein 3/Chinese materia medica/Ulcerative colitis/Review分类
中医学引用本文复制引用
覃小华,何晓金,崔锦珠,俞渊,钟焕英,段晓鑫,文亦磊,黄炳臣..中药基于NOD样受体热蛋白结构域相关蛋白3通路治疗溃疡性结肠炎的研究进展[J].中国医药科学,2025,15(2):12-15,4.基金项目
国家自然科学基金(82160880) （82160880）
广西中医药大学"岐黄工程"高层次人才团队培育项目(202411). （202411）
