中国药业2025，Vol.34Issue(4)：32-36,5.DOI:10.3969/j.issn.1006-4931.2025.04.009
基于AHM赋权联合TOPSIS法的西妥昔单抗注射液用药合理性评价
Evaluation of the Rationality of Cetuximab Injection Use Based on AHM Weighting Combined with TOPSIS Method
摘要
Abstract
Objective To provide a reference for the rational use of Cetuximab Injection in clinical practice.Methods Based on the drug instruction of Cetuximab Injection and its domestic and international diagnostic and treatment guidelines,the drug utilization evaluation(DUE)criteria for this drug were formulated according to relevant literature in the CNKI,WanFang,VIP,National Comprehensive Cancer Network(NCCN),PubMed databases and the actual clinical use of drugs in the hospital.A total of 239 medical records of inpatients treated with Cetuximab Injection from October 2021 to October 2023 were randomly selected from the Hospital Information System(HIS).The relative closeness(Ci)was calculated based on the attribute hierarchy model(AHM)weighting method combined with the technique for order preference by similarity to an ideal solution(TOPSIS)method to evaluate the medication rationality of patients.Results A total of 11 evaluation indicators were set,including physical condition,indications,usage and dosage,compatibility contraindications,precautions,contraindications,combined medication,clinical efficacy evaluation,adverse reaction monitoring and management,medication monitoring,and physicians' authority,with weights of 6.468%,13.930%,16.418%,5.970%,9.950%,3.980%,7.463%,10.448%,9.453%,12.935%,and 2.985%,respectively.The Ci of 239 cases was in the range of 38%to 100%,with 61 cases(67.36%)having a Ci of≥80%(rational),55 cases(23.01%)having a Ciof 60%to<80%(basically rational),and 23 cases(9.62%)having a Ci of<60%(irrational);irrational drug use mainly focused on usage,dosage,indications,monitoring and management of adverse reactions.Conclusion Based on AHM weighting combined with TOPSIS method,the rationality of Cetuximab Injection use can be reflected intuitively and accurately,which can provide a reference for optimizing its clinical use.关键词
属性层次模型赋权法/优劣解距离法/西妥昔单抗注射液/药物利用评价/合理用药Key words
attribute hierarchy model weighting method/technique for order preference by similarity to an ideal solution/Cetuximab Injection/drug utilization evaluation/rational srug use分类
药学引用本文复制引用
梁国栋,张威峰,葛明明,范娟..基于AHM赋权联合TOPSIS法的西妥昔单抗注射液用药合理性评价[J].中国药业,2025,34(4):32-36,5.基金项目
安徽省阜阳市"十四五"临床重点专科建设项目[阜卫医函[2023]41号]. （）
