中国医药科学2025，Vol.15Issue(2)：20-23,65,5.DOI:10.20116/j.issn2095-0616.2025.02.05
益生菌在重症急性胰腺炎相关性肺损伤治疗中的研究进展
Research progress of probiotics in the treatment of severe acute pancreatitis-associated lung injury
摘要
Abstract
Severe acute pancreatitis-associated lung injury(SAP-LI)is an early complication of acute pancreatitis,characterized by changes in gut microbiota in the early stages.Due to the bidirectional communication between the intestine and lungs,intestinal bacteria and their metabolites lead to the release of a large number of inflammatory factors,further exacerbating lung tissue damage.Probiotics are used in clinical practice for the protection and treatment of intestinal barrier function in various critical diseases,reducing the translocation of intestinal pathogenic bacteria to the lungs through blood circulation and lymphatic pathways,inhibiting the release of inflammatory factors,and providing great help in reducing lung injury.This article reviews the pathophysiological mechanisms of SAP-LI,the biological effects of probiotics,the impact of probiotics on gut microbiota balance,the gut lung axis,immune regulation,and the potential role of probiotics in SAP-LI treatment.关键词
重症急性胰腺炎/肺损伤/发病机制/益生菌/疗效Key words
Severe acute pancreatitis/Lung injury/Pathogenesis/Probiotics/Therapeutic effect分类
医药卫生引用本文复制引用
郭若琳,尹毅霞,王荣,罗永..益生菌在重症急性胰腺炎相关性肺损伤治疗中的研究进展[J].中国医药科学,2025,15(2):20-23,65,5.基金项目
广西壮族自治区研究生教育创新计划项目(YCSW2023509) （YCSW2023509）
广西肝胆疾病临床医学研究中心研究课题(桂科AD17129025-49) （桂科AD17129025-49）
广西壮族自治区卫生厅科研课题(Z2013779). （Z2013779）
