摘要
Abstract
Objective:To explore the application value of Yiqi Huayu Chubi Formula in the treatment of acute ST segment elevation myocardial infarction patients with intervention(Qi deficiency and blood stasis syndrome).Method:All patients with acute ST segment elevation myocardial infarction(Qi deficiency and blood stasis syndrome)treated in Huai'an Hospital,Huai'an City from June 2021 to January 2023 were randomly divided into two groups,68 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Yiqi Huayu Chubi Formula on the basis of the control group.The efficacy was compared after 4 weeks of treatment.Result:After treatment,the serum homocysteine(Hcy),D-dimer(D-D),interleukin-17(IL-17),procollagen Ⅲ N-terminal propeptide(PⅢNP)in the observation group were lower than those in the control group,and the level of superoxide dismutase(SOD)was higher than that in the control group,with statistical significance(P<0.05).After 48 hours of treatment,serum creatine kinase isoenzyme(CK-MB),serum B natriuretic peptide(BNP),and cardiac troponin T(cTnT)in the two groups were decreased(P<0.05).The serum levels of BNP,cTnT and CK-MB in the observation group were lower than those in the control group(P<0.05).After 2 weeks of treatment,the total TCM symptom score of the observation group was lower than that of the control group,and after 48 hours of treatment,the stroke volume(SV)and left ventricular ejection fraction(LVEF)were higher than those of the control group(P<0.05).After 2 weeks of treatment,the total effective rate of the observation group was 97.06%(66/68),which was higher than 80.88%(55/68)of the control group,the total incidence of complications in the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion:For interventional patients with acute ST segment elevation myocardial infarction(Qi deficiency and blood stasis syndrome),the combination of Yiqi Huayu Chubi Formula treatment can help reduce inflammatory response,promote myocardial cell repair,reduce the incidence of complications,and improve clinical efficacy.关键词
益气化瘀除痹方/急性ST段抬高型心肌梗死/介入/气虚血瘀证/白介素-17/超氧化物歧化酶/心肌细胞修复/并发症Key words
Yiqi Huayu Chubi Formula/Acute ST segment elevation myocardial infarction/Intervention/Qi deficiency and blood stasis syndrome/IL-17/SOD/Myocardial cell repair/Complications
