中国医药科学2025，Vol.15Issue(2)：40-44,5.DOI:10.20116/j.issn2095-0616.2025.02.10
极/超低出生体重早产儿颅内出血影响因素及NLR、PLR、D-D水平变化分析
Analysis of influencing factors of intracranial hemorrhage and changes of NLR,PLR and D-D levels in extremely/ultra-low birth weight premature infants
摘要
Abstract
Objective To analyze the influencing factors of intracranial hemorrhage and the changes of neutrophil to lymphocyte ratio(NLR),platelet and lymphocyte ratio(PLR)and D-dimer(D-D)levels in extremely/ultra-low birth weight premature infants.Methods From June 2018 to June 2023,464 cases of extremely/ultra-low birth weight premature infants admitted to the Maternity and Child Healthcare of Guangxi Zhuang Autonomous Region were selected as the research subjects,and were divided into bleeding group(n=88)and non-bleeding group(n=376)according to whether there was intracranial hemorrhage or not.The levels of NLR,PLR and D-D were compared between the two groups.Univariate and multivariate logistic regression was used to analyze the influencing factors of intracranial hemorrhage in extremely/ultra-low birth weight premature infants,and ROC curve was drawn to analyze the predictive value of NLR,PLR and D-D levels for intracranial hemorrhage in extremely/ultra-low birth weight premature infants.Results The levels of NLR,PLR and D-D in bleeding group were higher than those in non-bleeding group,and the differences were statistically significant(P<0.05).Multivariate logistic regression analysis showed that gestational age≤32 weeks(OR=2.056),vaginal delivery(OR=1.982),asphyxia(OR=1.766),elevated NLR(OR=2.059),elevated PLR(OR=2.109),and elevated D-D levels(OR=2.040)were all independent risk factors for intracranial hemorrhage in extremely/ultra-low birth weight premature infants(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of NLR,PLR,D-D levels,and combined detection were 0.836,0.836,0.802,and 0.947,respectively,indicating that combined detection was superior to single detection.Conclusion Intracranial hemorrhage in extremely/ultra-low birth weight premature infants is influenced by multiple factors,and NLR,PLR,and D-D levels can serve as auxiliary evaluation indicators for intracranial hemorrhage in extremely/ultra-low birth weight premature infants.关键词
早产儿/极/超低出生体重/颅内出血/中性粒细胞与淋巴细胞比值/血小板与淋巴细胞比值/D-二聚体Key words
Premature infants/Extremely/ultra-low birth weight/Intracranial hemorrhage/Neutrophil to lymphocyte ratio/Platelet and lymphocyte ratio/D-dimer分类
医药卫生引用本文复制引用
汪志萍,闭宏娟,李凌霄..极/超低出生体重早产儿颅内出血影响因素及NLR、PLR、D-D水平变化分析[J].中国医药科学,2025,15(2):40-44,5.基金项目
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20201060). （Z20201060）
