中国医学创新2025，Vol.22Issue(5)：39-43,5.DOI:10.3969/j.issn.1674-4985.2025.05.009
美罗培南联合经鼻高流量湿化氧疗对重症肺炎的治疗效果
Therapeutic Effect of Meropenem Combined with High Flow Nasal Humidified Therapy on Severe Pneumonia
李立 1黄伟 1许勇1
作者信息
- 1. 铜仁市人民医院急诊科 贵州 铜仁 554300
- 折叠
摘要
Abstract
Objective:To analyze the therapeutic effect of Meropenem combined with high flow nasal humidified therapy on patients with severe pneumonia.Method:A total of 80 patients with severe pneumonia admitted to Tongren People's Hospital from January 2020 to September 2024 were selected and divided into two groups according to different treatment plans.The control group(n=35)received conventional treatment and high flow nasal humidified therapy,and the observation group(n=45)was treated with Meropenem on the basis of the control group.The therapeutic effect,clinical symptoms and signs relief time,respiratory function,oxidative stress response and inflammatory factors were compared between the two groups.Result:The total effective rate of the observation group(97.78%)was higher than that of the control group(80.00%),and the relief time of symptoms and signs were earlier than those of the control group,the differences were statistically significant(P<0.05).After treatment,the work of breathing(WOB)of the observation group was lower than that of the control group,and the dynamic compliance(Cdyn)and oxygenation index were higher than those of the control group,the differences were statistically significant(P<0.05).After treatment,the superoxide dismutase(SOD)in the observation group was higher than that in the control group,and the levels of lipid peroxidation(LPO)and inflammatory factors were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Meropenem combined with high flow nasal humidified therapy can improve the therapeutic effect of severe pneumonia,improve the respiratory function of patients and reduce oxidative stress response and inflammatory response.关键词
美罗培南/经鼻高流量湿化氧疗/重症肺炎Key words
Meropenem/High flow nasal humidified therapy/Severe pneumonia引用本文复制引用
李立,黄伟,许勇..美罗培南联合经鼻高流量湿化氧疗对重症肺炎的治疗效果[J].中国医学创新,2025,22(5):39-43,5.
