超高效液相色谱串联质谱法检测16种中药乳膏制剂中抗真菌药OA
Detection of Antifungal Drugs in 16 Traditional Chinese Medicine Cream Preparations by UPLC-MS/MS
目的 建立检测中药外用制剂中抗真菌药物的超高效液相色谱串联质谱(UPLC-MS/MS)法.方法 以山东省疾病预防控制中心提供的 16 种中药乳膏制剂为检测对象.色谱柱为Agilent Poroshell SB-C18 柱(100 mm×2.1 mm,2.7µm),流动相为 0.1%甲酸水溶液-乙腈(含 0.1%甲酸水溶液),梯度洗脱,流速为 0.3 mL/min,柱温为 30℃,进样量为 2µL;电喷雾离子源,正离子、多反应监测模式,离子源温度为…查看全部>>
Objective To establish an ultra-high-performance liquid chromatography-mass spectrometry(UPLC-MS/MS)method for detecting antifungal drugs in external preparations of traditional Chinese medicine(TCM).Methods Sixteen types of TCM cream preparations provided by the Shandong Center for Disease Control and Prevention were used as the testing objects.The chromatographic column was an Agilent Poroshell SB-C18 column(100 mm×2.1 mm,2.7 µm),the mobile phase was 0.1%f…查看全部>>
杨晓;薛文静;焦洁
山东省青岛市政务服务和公共资源交易中心,山东 青岛 266071山东省青岛市食品药品检验研究院·国家药品监督管理局海洋中药质量研究与评价重点实验室,山东 青岛 266071北京理工大学,北京 100081
药学
非法添加超高效液相色谱串联质谱法抗真菌药物中药外用制剂
illegal additionUPLC-MS/MSantifungal drugexternal preparations of traditional Chinese medicine
《中国药业》 2025 (4)
84-87,4
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