中国医药科学2025，Vol.15Issue(2)：75-78,4.DOI:10.20116/j.issn2095-0616.2025.02.18
急性心肌梗死患者介入治疗前后血清miR-22水平变化与其早期预后的关系
Correlation between the changes of serum miR-22 level before and after interventional therapy and its early prognosis in patients with acute myocardial infarction
摘要
Abstract
Objective To investigate the correlation between the changes of serum miR-22 level before and after intervention and its early prognosis in patients with acute myocardial infarction.Methods A total of 62 patients with acute myocardial infarction who received interventional therapy in the Second Affiliated Hospital of Qiqihar Medical College from January to December 2023 were prospectively selected as the research objects,and they were divided into the good prognosis group and the poor prognosis group according to patient's early prognosis situations.Univariate and multivariate logistic regression were used to analyze the changes of serum miR-22 levels before and after intervention and the related impacting factors of early prognosis.Results After interventional therapy for a total of 62 patients,43 patients(accounting for 69.35%)had good early prognosis,while 19 patients(accounting for 30.65%)had poor early prognosis.Serum miR-22 in both groups decreased after treatment,and the serum miR-22 level in patients with good prognosis was significantly lower than that in patients with poor prognosis.Multivariate logistic regression analysis showed that the time from onset to admission(OR=2.533,95%CI:1.099-5.839,P=0.029)and the level of miR-22(OR=9.686,95%CI:1.398-67.124,P=0.022)were independent risk factors impacting the early prognosis of patients with acute myocardial infarction after interventional therapy.Conclusion The relative expression level of serum miR-22 in patients with acute myocardial infarction after interventional therapy is an independent risk factor impacting the early prognosis of patients with acute myocardial infarction after interventional therapy,which has a good predictive effect on the early prognosis of patients.关键词
miR-22/急性心肌梗死/介入治疗/早期预后Key words
MiR-22/Acute myocardial infarction/Interventional therapy/Early prognosis分类
医药卫生引用本文复制引用
马光宇,姜海瑞,李美娜,李彩杰,张宁宁..急性心肌梗死患者介入治疗前后血清miR-22水平变化与其早期预后的关系[J].中国医药科学,2025,15(2):75-78,4.基金项目
黑龙江省齐齐哈尔市科技计划联合引导项目(LSFGG-2023083). （LSFGG-2023083）
