中国医学创新2025，Vol.22Issue(5)：61-64,4.DOI:10.3969/j.issn.1674-4985.2025.05.014
洛铂术中灌注化疗辅助治疗中晚期结肠癌的效果
Effect of Intraoperative Perfusion Chemotherapy with Lobaplatin in Adjuvant Treatment of Middle and Advanced Colon Cancer
檀家俊 1周春根 1陈正鑫 1徐俊华 1朱勇1
作者信息
- 1. 南京中医药大学附属南京中医院(南京市中医院)肛肠中心 江苏 南京 210022
- 折叠
摘要
Abstract
Objective:To analyze the effect of intraoperative perfusion chemotherapy with Lobaplatin in adjuvant treatment of middle and advanced colon cancer.Method:A total of 80 patients with middle and advanced colon cancer admitted to Anorectal Center,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine from January to December 2022 were selected as the study objects,and were randomly divided into the conventional group(n=40,laparoscopic radical resection of colon cancer combined with adjuvant chemotherapy)and the observation group(n=40,combined with perfusion chemotherapy with Lobaplatin on the basis of conventional group).The total length of hospital stay,the incidence of postoperative complications,the incidence of chemotherapy adverse reactions and the levels of tumor markers were compared between the two groups.Result:There were no comparative difference in the incidence of postoperative complications,the incidence of chemotherapy adverse reactions and the total length of hospital stay between the two groups(P>0.05).After treatment,the carcinoembryonic antigen(CEA)level in observation group was significantly lower than that in conventional group(P<0.05).After treatment,there were no significant differences in carbohydrate antigen 19-9(CA19-9)and alpha-fetoprotein(AFP)between the two groups(P>0.05).Conclusion:Intraoperative perfusion chemotherapy with Lobaplatin in adjuvant treatment of middle and advanced colon cancer does not increase the risk of postoperative complications and chemotherapy adverse reactions,and can more effectively down-regulate the levels of tumor markers.关键词
结肠癌/腹腔镜结肠癌根治术/洛铂/灌注化疗Key words
Colon cancer/Laparoscopic radical resection of colon cancer/Lobaplatin/Perfusion chemotherapy引用本文复制引用
檀家俊,周春根,陈正鑫,徐俊华,朱勇..洛铂术中灌注化疗辅助治疗中晚期结肠癌的效果[J].中国医学创新,2025,22(5):61-64,4.
