中国药业2025，Vol.34Issue(4)：115-118,4.DOI:10.3969/j.issn.1006-4931.2025.04.028
多西环素与阿奇霉素治疗儿童支原体肺炎有效性、安全性及经济学比较
Effectiveness,Safety and Economy Comparison of Doxycycline and Azithromycin in the Treatment of Pediatric Mycoplasmal Pneumonia
摘要
Abstract
Objective To compare the efficacy,safety,and economy of doxycycline and azithromycin in the treatment of pediatric mycoplasmal pneumonia(MP).Methods A total of 354 children with MP(aged 8 to 14 years)admitted to the hospital from December 1,2022 to November 30,2023 were selected and divided into the control group(248 cases)and the observation group(106 cases)according to different medication regimens;their baseline data were collected and corrected by the propensity score matching(PSM).Both groups received symptomatic treatment,on this basis,the children in the control group received intravenous drip of Azithromycin for Injection,and the children in the observation group received intravenous drip of Doxycycline Hydrochloride for Injection.Both groups were treated for 8-14 d.The clinical efficacy(ecovery time of body temperature,disappearance time of pulmonary wet rales,disappearance time of cough,total clinical effective rate),safety(occurrence of adverse reactions),and economy(direct medical costs)of treatment between the two groups were compared.Results After PSM,103 children were included in each group,and there was no significantly difference in the baseline data between groups(P>0.05).The recovery time of body temperature,disappearance time of cough and disappearance time of pulmonary wet rales in the observation group was significantly less than that in the control group;the total clinical effective rate in the observation group was 93.21%,which was significantly higher than 87.38%in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of children(1.94%vs.1.94%,P>0.05).Compared with that in the control group,the treatment regimen in the observation group could save a cost of CNY 970.28,increase the treatment efficacy by 5.84%,with an incremental cost-effectiveness ratio of-166.14,which is consistent with the sensitivity analysis.Conclusion Doxycycline is more effective and economic than azithromycin in the treatment of pediatric MP,and the safety of both is comparable.关键词
多西环素/阿奇霉素/倾向性评分匹配/有效性/安全性/经济性Key words
doxycycline/azithromycin/propensity score matching/effectiveness/safety/economy分类
医药卫生引用本文复制引用
李红桥,夏雯,李兰,柯敏,余向东,饶志威,王雨来..多西环素与阿奇霉素治疗儿童支原体肺炎有效性、安全性及经济学比较[J].中国药业,2025,34(4):115-118,4.基金项目
湖北省科技计划项目[2020CFB868] （）
湖北省中医药管理局中医药科研立项项目[ZY2023F070] （）
湖北省黄石市社会科学研究项目[2023sk216]. （）
