组织工程与重建外科杂志2025，Vol.21Issue(1)：50-54,5.DOI:10.3969/j.issn.1673-0364.2025.01.008
自体细胞微移植提取物治疗雄激素性脱发的20例临床应用
Clinical application of autologous cell micrograft extracts for the treatment of androgenetic alopecia in 20 cases
摘要
Abstract
Objective To explore the efficacy and safety of autologous cell micrograft(ACM)extracts in the treatment of androgenetic alopecia(AGA).Methods The situation of AGA patients receiving ACM extract injection treatment in alopecia region was retrospectively analyzed.The cell count,survival rate and cell subtypes of ACM extract suspensions were analyzed by flow cytometry.The patients were followed up for(12±2)weeks after treatment.The effectiveness of the treatment was comprehensively evaluated by the photos before and after treatment,dermoscopy images and patient satisfaction questionnaire.At the same time,the injection area was observed for infection,swelling,rupture and other adverse reactions to evaluate the safety of treatment.Results The study included 20 patients with AGA.The suspension of ACM extract contained up to 106 highly viable cells,with DPs comprising the majority.Treatment with ACM extract resulted in significant improvement in hair loss appearance and a notable increase in hair coverage(P<0.05).Dermoscopic examination revealed a significant increase in overall hair density and a higher terminal-to-vellus hair ratio(T/V ratio).Patient satisfaction was high,with reports of reduced scalp oiliness and itching post-treatment.Additionally,ACM extract treatment can improve depigmentation.None of the 20 patients experienced any treatment-related adverse reactions during follow-up.Conclusion The application of ACM extract for the AGA treatment is safe and effective.This treatment method may serve as a novel approach to the AGA treatment as the injection of ACM extract was technologically simple and easy to use.关键词
自体细胞微移植/雄激素性秃发/毛发再生/毛乳头细胞/CD44Key words
Autologous cell micrograft/Androgenetic alopecia/Hair regrowth/Dermal papilla cells/CD44分类
临床医学引用本文复制引用
Tan Pohching,冷冰,刘清..自体细胞微移植提取物治疗雄激素性脱发的20例临床应用[J].组织工程与重建外科杂志,2025,21(1):50-54,5.基金项目
上海市科学技术委员会临床医学研究中心项目(22MC1940300). （22MC1940300）
