肿瘤防治研究2025，Vol.52Issue(2)：172-176,5.DOI:10.3971/j.issn.1000-8578.2025.24.0438
基于孟德尔随机化研究免疫细胞与胃癌发病风险的因果关系
Causal Relationships Between Immune Cells and Risk of Gastric Cancer:A Mendelian Randomization Study
摘要
Abstract
Objective To analyze the causal relationship between immune cell phenotype and gastric cancer.Methods Bidirectional two-sample Mendelian randomization(MR)analysis was used to select 731 genetic variants involving immune cell phenotypes from the GWAS dataset as instrumental variables.Inverse-variance weighting method(IVW),weighted median method(WM),and MR-Egger regression were used for sensitivity analysis.Cochran Q test,MR-Egger regression,MR-PRESSO method,and remain-one method were also conducted.Results Changes in the absolute count of IgD+B cells and CD14-CD16-cells were significantly associated with the risk of gastric cancer.A lower proportion of IgD+B cells was associated with a lower risk of gastric cancer(OR=0.86,95%CI:0.79-0.94),while an increased number of CD4-CD8-T cells was associated with an increased risk of gastric cancer(OR=1.2,95%CI:1.1-1.3).Conclusion A causal relationship exists between immune cell phenotype and the risk of gastric cancer.Changes in specific immune markers may regulate the development of gastric cancer by affecting the tumor microenvironment.关键词
免疫细胞/胃癌/孟德尔随机化/因果关系Key words
Immune cells/Gastric cancer/Mendelian randomization/Causal effects分类
医药卫生引用本文复制引用
何嘉伟,曹龙女,唐梦园,崔洪全..基于孟德尔随机化研究免疫细胞与胃癌发病风险的因果关系[J].肿瘤防治研究,2025,52(2):172-176,5.基金项目
Guidance Research Project of Suzhou Science and Technology Bureau(No.SYSD2021075) 苏州市科技局指导性课题(SYSD2021075) （No.SYSD2021075）
