中国肿瘤生物治疗杂志2025，Vol.32Issue(1)：30-37,8.DOI:10.3872/j.issn.1007-385x.2025.01.005
乙酰化修饰在甲状腺癌发生发展中的作用及其潜在的临床应用价值
Role of acetylation modification in the occurrence and development of thyroid cancer and its potential clinical application value
摘要
Abstract
Thyroid cancer is the most prevalent malignant tumor of the endocrine system,and its incidence has shown a significant upward trend in recent years.Acetylation,an important post-translational protein modification,is involved in regulating gene transcription,cell cycle progression,and invasion ability in various types of thyroid cancers.Additionally,histone deacetylase(HDAC)inhibitors have shown potential in the treatment of thyroid cancer.This article systematically reviews the biological functions and regulatory mechanisms of acetylation in the development and progression of thyroid cancer based on recent literature.Furthermore,it discusses the clinical application prospects of HDAC inhibitors,providing a solid theoretical basis and feasible therapeutic strategies for targeted therapy of thyroid cancer.关键词
甲状腺癌/乙酰化修饰/组蛋白去乙酰化酶抑制剂/靶向治疗Key words
thyroid cancer/acetylation modification/histone deacetylase(HDAC)inhibitor/targeted therapy分类
医药卫生引用本文复制引用
梁楠,敖倩,孙辉..乙酰化修饰在甲状腺癌发生发展中的作用及其潜在的临床应用价值[J].中国肿瘤生物治疗杂志,2025,32(1):30-37,8.基金项目
吉林省自然科学基金(No.YDZJ202201ZYTS112) （No.YDZJ202201ZYTS112）
