中外医学研究2025，Vol.23Issue(4)：166-169,4.DOI:10.14033/j.cnki.cfmr.2025.04.045
谷氨酰胺在急性肾损伤中的作用机制及临床应用新进展
New Progress in Mechanism of Action and Clinical Application of Glutamine in Acute Kidney Injury
摘要
Abstract
Acute kidney injury(AKI)is a global problem,affecting millions of patients worldwide,and over the past few decades,many research results have improved our understanding of AKI,standardizing the diagnostic criteria for AKI and influencing subsequent clinical treatment in Kidney Diseases:Improving Global Outcomes(KDIGO)in 2012.Glutamine(GLN)is a non-essential amino acid that is abundant in healthy humans,and previous studies have shown that GLN supplementation can be used to prevent new infections in uninfected patients or subsequent infections in critically ill patients who have already been infected,and is part of the clinical nutritional supplement regimen and recommended immunosuppressive individuals.With the continuous updating of AKI treatment guidelines and the in-depth exploration of GLN metabolism,more and more researchers have found that GLN plays a non-ignorable protective role in clinical AKI and critically ill patients.This review introduces the possible protective mechanism and clinical reference of GLN metabolism in the occurrence of AKI diseases,so as to provide a reference for better treatment of AKI patients.It can effectively protect the renal function of AKI patients,alleviate the disease symptoms and improve the prognosis of the disease.关键词
谷氨酰胺/急性肾损伤/作用机制/临床应用Key words
Glutamine/Acute kidney injury/Mechanism of action/Clinical application引用本文复制引用
巴·萨日娜,王顺..谷氨酰胺在急性肾损伤中的作用机制及临床应用新进展[J].中外医学研究,2025,23(4):166-169,4.基金项目
新疆维吾尔自治区自然科学基金资助项目(2022D01E24) （2022D01E24）
